N-Desmethyl Ribociclib

About N-Desmethyl Ribociclib

N-Desmethyl Ribociclib is a metabolite or degradation product of Ribociclib carrying the CAS registry number 1211441-59-6. Formula C22H28N8O, molecular weight 420.5 g/mol. The IUPAC name is 7-cyclopentyl-N-methyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide. Common synonyms include LEQ-803.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Analytical teams use this compound to identify metabolites and degradants of Ribociclib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Ribociclib

View every impurity, metabolite and intermediate we list for Ribociclib.

Ribociclib impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Desmethyl Ribociclib
Catalogue No.	VQ-035039
CAS Number	1211441-59-6
IUPAC name	7-cyclopentyl-N-methyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide
Molecular formula	C₂₂H₂₈N₈O
Molecular weight	420.5 g/mol
Exact mass	420.2386
Grade	Reference Standard
HSN code	38229090
InChIKey	ZSJOEUYXGLSYHY-UHFFFAOYSA-N
SMILES	CNC(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
PubChem CID	44818949

Physical properties
Physical form	Solid
LogP (XLogP3)	2
H-bond donors / acceptors	3 / 7
TPSA	100 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Desmethyl Ribociclib?

The CAS Registry Number of N-Desmethyl Ribociclib is 1211441-59-6. It is also known as LEQ-803.

What is the molecular formula and molecular weight of N-Desmethyl Ribociclib?

N-Desmethyl Ribociclib has the molecular formula C22H28N8O and a molecular weight of 420.5 g/mol. Its IUPAC name is 7-cyclopentyl-N-methyl-2-[(5-piperazin-1-yl-2-pyridinyl)amino]pyrrolo[2,3-d]pyrimidine-6-carboxamide.

What is N-Desmethyl Ribociclib used for?

N-Desmethyl Ribociclib is supplied as a characterised reference material related to Ribociclib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Desmethyl Ribociclib can I order?

We supply N-Desmethyl Ribociclib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Desmethyl Ribociclib?

Yes. Every lot of N-Desmethyl Ribociclib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Desmethyl Ribociclib be shipped internationally?

Yes. We export N-Desmethyl Ribociclib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.