Methotrexate Impurity 1

Name: Methotrexate Impurity 1
Brand: Vaqora Chemicals
SKU: VQ-049073

About Methotrexate Impurity 1

Listed under CAS 1308957-12-1, Methotrexate Impurity 1 is an impurity of Methotrexate available from Vaqora Chemicals. Formula C12H12ClNO5, molecular weight 285.68 g/mol. Systematically, it is named (2S)-2-[(3-chlorobenzoyl)amino]pentanedioic acid. Alternative names: Methotrexate Impurity 46 and (3-chlorobenzoyl)-L-glutamic acid.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

As a characterised impurity of Methotrexate, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Methotrexate Impurity 1 is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Methotrexate

View every impurity, metabolite and intermediate we list for Methotrexate.

Methotrexate impurities

Specifications & identifiers

Chemical identifiers
Product name	Methotrexate Impurity 1
Catalogue No.	VQ-049073
CAS Number	1308957-12-1
IUPAC name	(2S)-2-[(3-chlorobenzoyl)amino]pentanedioic acid
Molecular formula	C₁₂H₁₂ClNO₅
Molecular weight	285.68 g/mol
Exact mass	285.0404
Grade	Reference Standard
HSN code	38229090
InChIKey	TUUBBWPXOYFQDM-VIFPVBQESA-N
SMILES	C1=CC(=CC(=C1)Cl)C(=O)N[C@@H](CCC(=O)O)C(=O)O
PubChem CID	61152009

Physical properties
Physical form	Solid
LogP (XLogP3)	1.3
H-bond donors / acceptors	3 / 5
TPSA	104 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Methotrexate Impurity 1?

The CAS Registry Number of Methotrexate Impurity 1 is 1308957-12-1. It is also known as Methotrexate Impurity 46, (3-chlorobenzoyl)-L-glutamic acid.

What is the molecular formula and molecular weight of Methotrexate Impurity 1?

Methotrexate Impurity 1 has the molecular formula C12H12ClNO5 and a molecular weight of 285.68 g/mol. Its IUPAC name is (2S)-2-[(3-chlorobenzoyl)amino]pentanedioic acid.

What is Methotrexate Impurity 1 used for?

Methotrexate Impurity 1 is supplied as a characterised reference material related to Methotrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Methotrexate Impurity 1 can I order?

We supply Methotrexate Impurity 1 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methotrexate Impurity 1?

Yes. Every lot of Methotrexate Impurity 1 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methotrexate Impurity 1 be shipped internationally?

Yes. We export Methotrexate Impurity 1 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.