Impurity reference standards
Methotrexate impurities & reference standards
Characterised Methotrexate impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.
58reference materials
2isotope-labelled
COAHPLC · NMR · MS on request
Parent API: Methotrexate
59-05-2 · C20H22N8O5
(4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid
- CAS
- 52980-66-2
- Formula
- C20H22N8O5
- MW
- 454.4 g/mol
VQ-038365
(4S)-4-Amino-5-(dimethylamino)-5-oxopentanoic acid
- CAS
- 87733-70-8
- Formula
- C7H14N2O3
- MW
- 174.21 g/mol
VQ-049071
![1,5-Diethyl N-[2-(methylamino)benzoyl]-L-glutamate chemical structure](/media/structures/OBOHIWSCSNHNCI-AWEZNQCLSA-N.svg)
1,5-Diethyl N-[2-(methylamino)benzoyl]-L-glutamate
- CAS
- 1029980-84-4
- Formula
- C17H24N2O5
- MW
- 336.4 g/mol
VQ-035406
![1,5-Diethyl N-[3-(methylamino)benzoyl]-L-glutamate chemical structure](/media/structures/CSYABNNOSSRTQX-AWEZNQCLSA-N.svg)
1,5-Diethyl N-[3-(methylamino)benzoyl]-L-glutamate
- CAS
- 2820151-35-5
- Formula
- C17H24N2O5
- MW
- 336.4 g/mol
VQ-044722
2,4-Diamino-6-(hydroxymethyl)pteridine Hydrochloride
- CAS
- 73978-41-3
- Formula
- C7H9ClN6O
- MW
- 228.64 g/mol
VQ-031822
![4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl) methyl]amino]benzoic Acid Methyl Ester chemical structure](/media/structures/YAFRAOCZBREAAZ-UHFFFAOYSA-N.svg)
4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl) methyl]amino]benzoic Acid Methyl Ester
- CAS
- 34794-87-1
- Formula
- C15H14N6O3
- MW
- 326.31 g/mol
In stock
FAQs — Methotrexate impurities
Which Methotrexate impurities do you supply?
We list 58 Methotrexate-related reference materials, including process impurities, degradation products, stable-isotope-labelled standards and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.
What are Methotrexate impurity standards used for?
They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).
Can you synthesise a Methotrexate impurity that is not listed?
Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.
Request Methotrexate impurity standards
We reply within one business day with price, pack options, lead time and documentation.