Acalabrutanib Intermediate 1

Name: Acalabrutanib Intermediate 1
Brand: Vaqora Chemicals
SKU: VQ-013183

About Acalabrutanib Intermediate 1

Acalabrutanib Intermediate 1 (CAS 1418307-17-1) is a process intermediate or related compound of Acalabrutinib offered by Vaqora Chemicals. Formula C18H19ClN4O3, molecular weight 374.8 g/mol. The IUPAC name is benzyl 2-[(3-chloropyrazin-2-yl)methylcarbamoyl]pyrrolidine-1-carboxylate.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

It is a process intermediate or related compound in the synthesis of Acalabrutinib, useful for route development, impurity fate-and-purge studies and analytical method development. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. This item is currently in stock for prompt dispatch.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Acalabrutinib

View every impurity, metabolite and intermediate we list for Acalabrutinib.

Acalabrutinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Acalabrutanib Intermediate 1
Catalogue No.	VQ-013183
CAS Number	1418307-17-1
IUPAC name	benzyl 2-[(3-chloropyrazin-2-yl)methylcarbamoyl]pyrrolidine-1-carboxylate
Molecular formula	C₁₈H₁₉ClN₄O₃
Molecular weight	374.8 g/mol
Exact mass	374.1146
Grade	Reference Standard
HSN code	2933
InChIKey	FGJFNCMHEQQNJP-UHFFFAOYSA-N
SMILES	C1CC(N(C1)C(=O)OCC2=CC=CC=C2)C(=O)NCC3=NC=CN=C3Cl
PubChem CID	118865439

Physical properties
Physical form	Solid
LogP (XLogP3)	1.8
H-bond donors / acceptors	1 / 5
TPSA	84.4 Å²

Safety & hazard information (GHS)

Hazard statements

H412Harmful to aquatic life with long lasting effects

Precautionary statements: P273, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Acalabrutanib Intermediate 1?

The CAS Registry Number of Acalabrutanib Intermediate 1 is 1418307-17-1. It is also known as Benzyl (2S)-2-{[(3-chloro-2-pyrazinyl)methyl]carbamoyl}-1-pyrrolidinecarboxylate, (S)-Benzyl 2-((3-chloropyrazin-2-yl)methylcarbamoyl)pyrrolidine-1-carboxylate, Benzyl 2-{[(3-chloropyrazin-2-yl)methyl]carbamoyl}pyrrolidine-1-carboxylate.

What is the molecular formula and molecular weight of Acalabrutanib Intermediate 1?

Acalabrutanib Intermediate 1 has the molecular formula C18H19ClN4O3 and a molecular weight of 374.8 g/mol. Its IUPAC name is benzyl 2-[(3-chloropyrazin-2-yl)methylcarbamoyl]pyrrolidine-1-carboxylate.

What is Acalabrutanib Intermediate 1 used for?

Acalabrutanib Intermediate 1 is supplied as a characterised reference material related to Acalabrutinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Acalabrutanib Intermediate 1 can I order?

We supply Acalabrutanib Intermediate 1 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Acalabrutanib Intermediate 1?

Yes. Every lot of Acalabrutanib Intermediate 1 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Acalabrutanib Intermediate 1 be shipped internationally?

Yes. We export Acalabrutanib Intermediate 1 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.