Acalabrutanib Intermediate 3

Name: Acalabrutanib Intermediate 3
Brand: Vaqora Chemicals
SKU: VQ-013185

About Acalabrutanib Intermediate 3

Vaqora Chemicals supplies Acalabrutanib Intermediate 3, a process intermediate or related compound of Acalabrutinib registered under CAS number 1420478-87-0. Formula C18H16BrClN4O2, molecular weight 435.7 g/mol. The IUPAC name is benzyl (2S)-2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

It is a process intermediate or related compound in the synthesis of Acalabrutinib, useful for route development, impurity fate-and-purge studies and analytical method development. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. Stock is available for quick dispatch.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Acalabrutinib

View every impurity, metabolite and intermediate we list for Acalabrutinib.

Acalabrutinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Acalabrutanib Intermediate 3
Catalogue No.	VQ-013185
CAS Number	1420478-87-0
IUPAC name	benzyl (2S)-2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
Molecular formula	C₁₈H₁₆BrClN₄O₂
Molecular weight	435.7 g/mol
Exact mass	434.0145
Grade	Reference Standard
HSN code	2933
InChIKey	BQNYTGLJPKJADU-ZDUSSCGKSA-N
SMILES	C1C[C@H](N(C1)C(=O)OCC2=CC=CC=C2)C3=NC(=C4N3C=CN=C4Cl)Br
PubChem CID	86720303

Physical properties
Physical form	Solid
LogP (XLogP3)	4.5
H-bond donors / acceptors	0 / 4
TPSA	59.7 Å²
Synonyms	(S)-Benzyl 2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate, Benzyl (2S)-2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)-1-pyrrolidinecarboxylate, benzyl (S)-2-(1-Bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate, benzyl (2S)-2-{1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl}pyrrolidine-1-carboxylate, Benzyl 2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate, (S)-, Phenylmethyl (2S)-2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)-1-pyrrolidinecarboxylate

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P319, P321, P330, P332 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Acalabrutanib Intermediate 3?

The CAS Registry Number of Acalabrutanib Intermediate 3 is 1420478-87-0. It is also known as (S)-Benzyl 2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate, Benzyl (2S)-2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)-1-pyrrolidinecarboxylate, benzyl (S)-2-(1-Bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate.

What is the molecular formula and molecular weight of Acalabrutanib Intermediate 3?

Acalabrutanib Intermediate 3 has the molecular formula C18H16BrClN4O2 and a molecular weight of 435.7 g/mol. Its IUPAC name is benzyl (2S)-2-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate.

What is Acalabrutanib Intermediate 3 used for?

Acalabrutanib Intermediate 3 is supplied as a characterised reference material related to Acalabrutinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Acalabrutanib Intermediate 3 can I order?

We supply Acalabrutanib Intermediate 3 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Acalabrutanib Intermediate 3?

Yes. Every lot of Acalabrutanib Intermediate 3 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Acalabrutanib Intermediate 3 be shipped internationally?

Yes. Acalabrutanib Intermediate 3 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.