Diphenhydramine HCl

About Diphenhydramine HCl

Diphenhydramine HCl is a respiratory / antiallergic API (IP/BP/USP grade) carrying the CAS registry number 147-24-0. With the molecular formula C17H22ClNO, it has a molar mass of 291.8 g/mol. The IUPAC name is 2-benzhydryloxy-N,N-dimethylethanamine. Hydrochloride. Alternative names: Allergival and Bendylate.

It is supplied as a white or almost white crystalline powder. Keep the container tightly sealed and store it in a cool, dry area. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

This API belongs to our respiratory and antiallergic APIs portfolio and is supplied to IP/BP/USP specifications for formulators, contract manufacturers and generic drug developers. It is used across pharmaceutical manufacturing.

We offer Diphenhydramine HCl in 1 kg, 5 kg and 25 kg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Pharmaceutical formulation
Generic drug development

Industries

Related to Diphenhydramine

View every impurity, metabolite and intermediate we list for Diphenhydramine.

Diphenhydramine impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Diphenhydramine HCl
Catalogue No.	VQ-004168
CAS Number	147-24-0
IUPAC name	2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride
Molecular formula	C₁₇H₂₂ClNO
Molecular weight	291.8 g/mol
Exact mass	291.139
Grade	IP/BP/USP
HSN code	2933
InChIKey	PCHPORCSPXIHLZ-UHFFFAOYSA-N
SMILES	CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2.Cl
PubChem CID	8980

Physical properties
Physical form	Powder
Appearance	White or almost white crystalline powder
H-bond donors / acceptors	1 / 2
TPSA	12.5 Å²
Synonyms	Allergival, Bendylate, Denydryl, Eldadryl, Hydramine, Beldin, Dimedrol hydrochloride, Vicks Formula 44, Wehydryl, Resmin, Benzhydramine hydrochloride, Difenhydramine hydrochloride

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements: P264, P270, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Diphenhydramine HCl?

The CAS Registry Number of Diphenhydramine HCl is 147-24-0. It is also known as Allergival, Bendylate, Denydryl.

What is the molecular formula and molecular weight of Diphenhydramine HCl?

Diphenhydramine HCl has the molecular formula C17H22ClNO and a molecular weight of 291.8 g/mol.

What is Diphenhydramine HCl used for?

Diphenhydramine HCl is supplied as a characterised reference material related to Diphenhydramine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Diphenhydramine HCl can I order?

We supply Diphenhydramine HCl in IP/BP/USP grade, in 1 kg, 5 kg, 25 kg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Diphenhydramine HCl?

Yes. Every lot of Diphenhydramine HCl is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Diphenhydramine HCl be shipped internationally?

Yes. Diphenhydramine HCl is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.