Sacubitril Diacid Impurity

Name: Sacubitril Diacid Impurity
Brand: Vaqora Chemicals
SKU: VQ-007256

About Sacubitril Diacid Impurity

Listed under CAS 149709-44-4, Sacubitril Diacid Impurity is a metabolite or degradation product of Sacubitril available from Vaqora Chemicals. The compound has the formula C22H25NO5, corresponding to a molecular weight of 383.4 g/mol. The IUPAC name is (2R,4S)-4-(3-carboxypropanoylamino)-2-methyl-5-(4-phenylphenyl)pentanoic acid. It is also known as Desethyl Sacubitril or Sacubitrilat.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Danger” with 2 hazard statements. Review the Safety Data Sheet before use.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Sacubitril, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. Stock is available for quick dispatch.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Sacubitril

View every impurity, metabolite and intermediate we list for Sacubitril.

Sacubitril impurities

Specifications & identifiers

Chemical identifiers
Product name	Sacubitril Diacid Impurity
Catalogue No.	VQ-007256
CAS Number	149709-44-4
IUPAC name	(2R,4S)-4-(3-carboxypropanoylamino)-2-methyl-5-(4-phenylphenyl)pentanoic acid
Molecular formula	C₂₂H₂₅NO₅
Molecular weight	383.4 g/mol
Exact mass	383.1733
Grade	Reference Standard
HSN code	38229090
InChIKey	DOBNVUFHFMVMDB-BEFAXECRSA-N
SMILES	C[C@H](C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O)C(=O)O
PubChem CID	10430040

Physical properties
Physical form	Solid
LogP (XLogP3)	3
H-bond donors / acceptors	3 / 5
TPSA	104 Å²
Synonyms	Desethyl Sacubitril, (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic Acid, (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic Acid, (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid, Sacubitrilat, LBQ-657, (2R,4S)-5-(Biphenyl-4-yl)-4-((3-carboxypropionyl)amino)-2-methylpentanoic acid, (2R,4S)-5-{[1,1'-biphenyl]-4-yl}-4-(3-carboxypropanamido)-2-methylpentanoic acid, sacubitrilate, (2R,4S)-4-((4-hydroxy-4-oxobutanoyl)amino)-2-methyl-5-(4-phenylphenyl)pentanoic acid, (2R,4S)-4-[(4-hydroxy-4-oxobutanoyl)amino]-2-methyl-5-(4-phenylphenyl)pentanoic acid, (2R,4S)-5-((1,1'-biphenyl)-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H336May cause drowsiness or dizziness
H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements: P260, P261, P264, P270, P271, P304 + P340, P319, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Sacubitril Diacid Impurity?

The CAS Registry Number of Sacubitril Diacid Impurity is 149709-44-4. It is also known as Desethyl Sacubitril, (2R,4S)-4-[(3-Carboxy-1-oxopropyl)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic Acid, (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic Acid.

What is the molecular formula and molecular weight of Sacubitril Diacid Impurity?

Sacubitril Diacid Impurity has the molecular formula C22H25NO5 and a molecular weight of 383.4 g/mol. Its IUPAC name is (2R,4S)-4-(3-carboxypropanoylamino)-2-methyl-5-(4-phenylphenyl)pentanoic acid.

What is Sacubitril Diacid Impurity used for?

Sacubitril Diacid Impurity is supplied as a characterised reference material related to Sacubitril. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Sacubitril Diacid Impurity can I order?

We supply Sacubitril Diacid Impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Sacubitril Diacid Impurity?

Yes. Every lot of Sacubitril Diacid Impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Sacubitril Diacid Impurity be shipped internationally?

Yes. Sacubitril Diacid Impurity is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.