Selumetinib Nitroso Impurity-2

About Selumetinib Nitroso Impurity-2

Selumetinib Nitroso Impurity-2 is a nitrosamine impurity of Selumetinib carrying the CAS registry number 15775-74-3, specified at 56% purity. With the molecular formula C21H30O2, it has a molar mass of 323.5 g/mol. Common synonyms include 2000-66-0 (Unlabelled) and Selumetinib Nitroso Impurity 19.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

We offer Selumetinib Nitroso Impurity-2 in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. Stock is available for quick dispatch.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Selumetinib

View every impurity, metabolite and intermediate we list for Selumetinib.

Selumetinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Selumetinib Nitroso Impurity-2
Catalogue No.	VQ-007045
CAS Number	15775-74-3
IUPAC name	(8S,9S,10R,13S,14S,17S)-2,2,4,6,6,17-hexadeuterio-10,13-dimethyl-17-(2,2,2-trideuterioacetyl)-7,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one
Molecular formula	C₂₁H₃₀O₂
Molecular weight	323.5 g/mol
Exact mass	323.2811
Grade	Reference Standard
Purity / assay	56%
HSN code	38229090
InChIKey	RJKFOVLPORLFTN-PQIPVKAESA-N
SMILES	[2H]C1=C2[C@](CC(C1=O)([2H])[2H])([C@H]3CC[C@]4([C@H]([C@@H]3CC2([2H])[2H])CC[C@]4([2H])C(=O)C([2H])([2H])[2H])C)C
PubChem CID	71309321

Physical properties
Physical form	Solid
LogP (XLogP3)	3.9
H-bond donors / acceptors	0 / 2
TPSA	34.1 Å²

Safety & hazard information (GHS)

Health hazard

Signal word: Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Selumetinib Nitroso Impurity-2?

The CAS Registry Number of Selumetinib Nitroso Impurity-2 is 15775-74-3. It is also known as 2000-66-0 (Unlabelled), Selumetinib Nitroso Impurity 19, TMIH-0455.

What is the molecular formula and molecular weight of Selumetinib Nitroso Impurity-2?

Selumetinib Nitroso Impurity-2 has the molecular formula C21H30O2 and a molecular weight of 323.5 g/mol. Its IUPAC name is (8S,9S,10R,13S,14S,17S)-2,2,4,6,6,17-hexadeuterio-10,13-dimethyl-17-(2,2,2-trideuterioacetyl)-7,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one.

What is Selumetinib Nitroso Impurity-2 used for?

Selumetinib Nitroso Impurity-2 is supplied as a characterised reference material related to Selumetinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Selumetinib Nitroso Impurity-2 can I order?

We supply Selumetinib Nitroso Impurity-2 in Reference Standard (56%) grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Selumetinib Nitroso Impurity-2?

Yes. Every lot of Selumetinib Nitroso Impurity-2 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Selumetinib Nitroso Impurity-2 be shipped internationally?

Yes. Selumetinib Nitroso Impurity-2 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.