Ibrutinib Metabolite M37

About Ibrutinib Metabolite M37

Ibrutinib Metabolite M37 is a metabolite or degradation product of Ibrutinib carrying the CAS registry number 1654820-87-7. With the molecular formula C25H26N6O4, it has a molar mass of 474.5 g/mol. The IUPAC name is 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2,3-dihydroxypropan-1-one. Alternative names: Dihydrodiol Ibrutinib and Ibrutinib Dihydrodiol R-Isomer.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

It is used in metabolite identification, stability-indicating method development and impurity profiling of Ibrutinib, as well as in QC testing and ANDA/DMF documentation. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Ibrutinib Metabolite M37 in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Ibrutinib

View every impurity, metabolite and intermediate we list for Ibrutinib.

Ibrutinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Ibrutinib Metabolite M37
Catalogue No.	VQ-026095
CAS Number	1654820-87-7
IUPAC name	1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2,3-dihydroxypropan-1-one
Molecular formula	C₂₅H₂₆N₆O₄
Molecular weight	474.5 g/mol
Exact mass	474.2016
Grade	Reference Standard
HSN code	38229090
InChIKey	NWKPMPRXJGMTKQ-DIAVIDTQSA-N
SMILES	C1C[C@H](CN(C1)C(=O)C(CO)O)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N
PubChem CID	91971609

Physical properties
Physical form	Solid
LogP (XLogP3)	1.7
H-bond donors / acceptors	3 / 8
TPSA	140 Å²
Synonyms	Dihydrodiol Ibrutinib, Ibrutinib Dihydrodiol R-Isomer, Dihydrodiol-Ibrutinib, Ibrutinib Impurity 48, Dihydrodiol Ibrutinib, PCI-45227, Ibrutinib Impurity 13 (Mixture of Diastereomers)

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Ibrutinib Metabolite M37?

The CAS Registry Number of Ibrutinib Metabolite M37 is 1654820-87-7. It is also known as Dihydrodiol Ibrutinib, Ibrutinib Dihydrodiol R-Isomer, Dihydrodiol-Ibrutinib.

What is the molecular formula and molecular weight of Ibrutinib Metabolite M37?

Ibrutinib Metabolite M37 has the molecular formula C25H26N6O4 and a molecular weight of 474.5 g/mol. Its IUPAC name is 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-2,3-dihydroxypropan-1-one.

What is Ibrutinib Metabolite M37 used for?

Ibrutinib Metabolite M37 is supplied as a characterised reference material related to Ibrutinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Ibrutinib Metabolite M37 can I order?

We supply Ibrutinib Metabolite M37 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Ibrutinib Metabolite M37?

Yes. Every lot of Ibrutinib Metabolite M37 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Ibrutinib Metabolite M37 be shipped internationally?

Yes. We export Ibrutinib Metabolite M37 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.