Aprepitant

Name: Aprepitant
Brand: Vaqora Chemicals
SKU: VQ-007320

About Aprepitant

Listed under CAS 170729-80-3, Aprepitant is a high-purity reference standard of Aprepitant available from Vaqora Chemicals. Formula C23H21F7N4O3, molecular weight 534.4 g/mol. Common synonyms include Emend and MK-869.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Aprepitant, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Aprepitant in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide. Stock is available for quick dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Aprepitant

View every impurity, metabolite and intermediate we list for Aprepitant.

Aprepitant impurities

Specifications & identifiers

Chemical identifiers
Product name	Aprepitant
Catalogue No.	VQ-007320
CAS Number	170729-80-3
IUPAC name	3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,4-dihydro-1,2,4-triazol-5-one
Molecular formula	C₂₃H₂₁F₇N₄O₃
Molecular weight	534.4 g/mol
Exact mass	534.1502
Grade	Reference Standard
HSN code	38229090
InChIKey	ATALOFNDEOCMKK-OITMNORJSA-N
SMILES	C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F
PubChem CID	135413536

Physical properties
Physical form	Solid
LogP (XLogP3)	4.2
H-bond donors / acceptors	2 / 12
TPSA	75.2 Å²
Synonyms	Emend, MK-869, ONO-7436, MK 869, Emend (TN), Aprepitant (MK-0869), Aprepitant CRS, Cinvanti (TN), aprepitant, form I, Aponvie (TN), aprepitant, form II, Aprepitant (Standard)

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Warning

Hazard statements

H319Causes serious eye irritation
H351Suspected of causing cancer
H373May causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P264 + P265, P273, P280, P305 + P351 + P338, P318, P319, P337 + P317, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Aprepitant?

The CAS Registry Number of Aprepitant is 170729-80-3. It is also known as Emend, MK-869, ONO-7436.

What is the molecular formula and molecular weight of Aprepitant?

Aprepitant has the molecular formula C23H21F7N4O3 and a molecular weight of 534.4 g/mol. Its IUPAC name is 3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,4-dihydro-1,2,4-triazol-5-one.

What is Aprepitant used for?

Aprepitant is supplied as a characterised reference material related to Aprepitant. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Aprepitant can I order?

We supply Aprepitant in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Aprepitant?

Yes. Every lot of Aprepitant is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Aprepitant be shipped internationally?

Yes. Aprepitant is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.