N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitro… 179552-74-0

Name: N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
Brand: Vaqora Chemicals
SKU: VQ-028799

About N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine

Listed under CAS 179552-74-0, N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine is an impurity of Afatinib available from Vaqora Chemicals. With the molecular formula C15H10ClFN4O3, it has a molar mass of 348.71 g/mol. Alternative names: Dacomitinib Intermediate 2.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

Pharmaceutical QC and development laboratories use this impurity standard of Afatinib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
Catalogue No.	VQ-028799
CAS Number	179552-74-0
IUPAC name	N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
Molecular formula	C₁₅H₁₀ClFN₄O₃
Molecular weight	348.71 g/mol
Exact mass	348.0425
Grade	Reference Standard
HSN code	38229090
InChIKey	VKEKKVCWODTGAP-UHFFFAOYSA-N
SMILES	COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)[N+](=O)[O-]
PubChem CID	21847811

Physical properties
Physical form	Solid
LogP (XLogP3)	3.9
H-bond donors / acceptors	1 / 7
TPSA	92.9 Å²
Synonyms	4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-, N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-quinazolinamine, (3-Chloro-4-fluoro-phenyl)-(7-methoxy-6-nitro-quinazolin-4-yl)-amine, Dacomitinib Intermediate 2, 4-(3-chloro-4-fluorophenylamino)-6-nitro-7-methoxyquinazoline, N - (3-Chloro-4-fluorophenyl) -7-methoxy-6-nitroquinoline-4-amine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-Quinazolinam..., Dacomitinib Intermediate 2N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine?

The CAS Registry Number of N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine is 179552-74-0. It is also known as 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitro-, N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-quinazolinamine, (3-Chloro-4-fluoro-phenyl)-(7-methoxy-6-nitro-quinazolin-4-yl)-amine.

What is the molecular formula and molecular weight of N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine?

N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine has the molecular formula C15H10ClFN4O3 and a molecular weight of 348.71 g/mol. Its IUPAC name is N-(3-chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine.

What is N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine used for?

N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine can I order?

We supply N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine?

Yes. Every lot of N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine be shipped internationally?

Yes. We export N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.