Sacubitril Impurity 49 (Hydrochloride)

About Sacubitril Impurity 49 (Hydrochloride)

Sacubitril Impurity 49 (Hydrochloride) is an impurity of Sacubitril carrying the CAS registry number 1933501-50-8 at a purity of 99%. With the molecular formula C19H24ClNO2, it has a molar mass of 333.8 g/mol. Systematically, it is named methyl (2R,4S)-4-amino-2-methyl-5-(4-phenylphenyl)pentanoate. Hydrochloride. Alternative names: Sacubitril Impurity 17 and Sacubitril Impurity 27.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

As a characterised impurity of Sacubitril, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide. Stock is available for quick dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Sacubitril

View every impurity, metabolite and intermediate we list for Sacubitril.

Sacubitril impurities

Specifications & identifiers

Chemical identifiers
Product name	Sacubitril Impurity 49 (Hydrochloride)
Catalogue No.	VQ-005859
CAS Number	1933501-50-8
Other CAS	1933501-49-5
IUPAC name	methyl (2R,4S)-4-amino-2-methyl-5-(4-phenylphenyl)pentanoate;hydrochloride
Molecular formula	C₁₉H₂₄ClNO₂
Molecular weight	333.8 g/mol
Exact mass	333.1496
Grade	Reference Standard
Purity / assay	99%
HSN code	38229090
InChIKey	JXCBCAOTPDLFLH-CQZNTPMBSA-N
SMILES	C[C@H](C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)N)C(=O)OC.Cl
PubChem CID	127255947

Physical properties
Physical form	Solid
H-bond donors / acceptors	2 / 3
TPSA	52.3 Å²
Synonyms	(2R,4S)-Methyl 5-([1,1′-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride, Methyl (αR,γS)-γ-amino-α-methyl[1,1′-biphenyl]-4-pentanoate hydrochloride, Methyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride, Sacubitril Impurity 17, (2R,4S)-Methyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride, Sacubitril Impurity 27, LCZ-696 Impurity 92, -biphenyl]-4-pentanoic Acid Methyl Ester Hydrochloride, -biphenyl]-4-pentanoic Acid Methyl Ester Hydrochloride"

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Sacubitril Impurity 49 (Hydrochloride)?

The CAS Registry Number of Sacubitril Impurity 49 (Hydrochloride) is 1933501-50-8. It is also known as (2R,4S)-Methyl 5-([1,1′-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride, Methyl (αR,γS)-γ-amino-α-methyl[1,1′-biphenyl]-4-pentanoate hydrochloride, Methyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride.

What is the molecular formula and molecular weight of Sacubitril Impurity 49 (Hydrochloride)?

Sacubitril Impurity 49 (Hydrochloride) has the molecular formula C19H24ClNO2 and a molecular weight of 333.8 g/mol.

What is Sacubitril Impurity 49 (Hydrochloride) used for?

Sacubitril Impurity 49 (Hydrochloride) is supplied as a characterised reference material related to Sacubitril. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Sacubitril Impurity 49 (Hydrochloride) can I order?

We supply Sacubitril Impurity 49 (Hydrochloride) in Reference Standard (99%) grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Sacubitril Impurity 49 (Hydrochloride)?

Yes. Every lot of Sacubitril Impurity 49 (Hydrochloride) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Sacubitril Impurity 49 (Hydrochloride) be shipped internationally?

Yes. We export Sacubitril Impurity 49 (Hydrochloride) worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.