3-Chloro-4-(3-fluorobenzyloxy)aniline

Name: 3-Chloro-4-(3-fluorobenzyloxy)aniline
Brand: Vaqora Chemicals
SKU: VQ-026366

About 3-Chloro-4-(3-fluorobenzyloxy)aniline

Vaqora Chemicals supplies 3-Chloro-4-(3-fluorobenzyloxy)aniline, an impurity of Lapatinib registered under CAS number 202197-26-0. The compound has the formula C13H11ClFNO, corresponding to a molecular weight of 251.68 g/mol. The IUPAC name is 3-chloro-4-[(3-fluorophenyl)methoxy]aniline. It is also known as 3-Chloro-4-(3-fluoro-benzyloxy)-phenylamine or 4-(3-fluorobenzyloxy)-3-chlorobenzenamine.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

This Lapatinib impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies 3-Chloro-4-(3-fluorobenzyloxy)aniline in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Lapatinib

View every impurity, metabolite and intermediate we list for Lapatinib.

Lapatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	3-Chloro-4-(3-fluorobenzyloxy)aniline
Catalogue No.	VQ-026366
CAS Number	202197-26-0
IUPAC name	3-chloro-4-[(3-fluorophenyl)methoxy]aniline
Molecular formula	C₁₃H₁₁ClFNO
Molecular weight	251.68 g/mol
Exact mass	251.0513
Grade	Reference Standard
HSN code	38229090
InChIKey	AYPFEYDGZDPAPE-UHFFFAOYSA-N
SMILES	C1=CC(=CC(=C1)F)COC2=C(C=C(C=C2)N)Cl
PubChem CID	7059263

Physical properties
Physical form	Solid
LogP (XLogP3)	3.4
H-bond donors / acceptors	1 / 3
TPSA	35.3 Å²
Synonyms	3-Chloro-4-[(3-fluorophenyl)methoxy]benzenamine, 3-Chloro-4-((3-fluorophenyl)methoxy)benzenamine, Benzenamine, 3-chloro-4-[(3-fluorophenyl)methoxy]-, 3-chloro-4-(3-fluorobenzyloxy)aniline, AldrichCPR, 3-Chloro-4-(3-fluoro-benzyloxy)-phenylamine, 4-(3-fluorobenzyloxy)-3-chlorobenzenamine, 4-(3-fluorobenzyloxy)-3-chloroaniline, 3-chloro-4(m-fluoro-benzyloxy)-aniline

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H341Suspected of causing genetic defects
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P264, P270, P273, P280, P301 + P317, P318, P319, P330, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 3-Chloro-4-(3-fluorobenzyloxy)aniline?

The CAS Registry Number of 3-Chloro-4-(3-fluorobenzyloxy)aniline is 202197-26-0. It is also known as 3-Chloro-4-[(3-fluorophenyl)methoxy]benzenamine, 3-Chloro-4-((3-fluorophenyl)methoxy)benzenamine, Benzenamine, 3-chloro-4-[(3-fluorophenyl)methoxy]-.

What is the molecular formula and molecular weight of 3-Chloro-4-(3-fluorobenzyloxy)aniline?

3-Chloro-4-(3-fluorobenzyloxy)aniline has the molecular formula C13H11ClFNO and a molecular weight of 251.68 g/mol. Its IUPAC name is 3-chloro-4-[(3-fluorophenyl)methoxy]aniline.

What is 3-Chloro-4-(3-fluorobenzyloxy)aniline used for?

3-Chloro-4-(3-fluorobenzyloxy)aniline is supplied as a characterised reference material related to Lapatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 3-Chloro-4-(3-fluorobenzyloxy)aniline can I order?

We supply 3-Chloro-4-(3-fluorobenzyloxy)aniline in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 3-Chloro-4-(3-fluorobenzyloxy)aniline?

Yes. Every lot of 3-Chloro-4-(3-fluorobenzyloxy)aniline is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 3-Chloro-4-(3-fluorobenzyloxy)aniline be shipped internationally?

Yes. 3-Chloro-4-(3-fluorobenzyloxy)aniline is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.