Afatinib Malonic acid Adduct

About Afatinib Malonic acid Adduct

Afatinib Malonic acid Adduct is an impurity of Afatinib carrying the CAS registry number 2413212-27-6. Formula C27H27ClFN5O7, molecular weight 588.0 g/mol.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Pharmaceutical QC and development laboratories use this impurity standard of Afatinib to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Afatinib Malonic acid Adduct in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Afatinib Malonic acid Adduct
Catalogue No.	VQ-035431
CAS Number	2413212-27-6
IUPAC name	2-(3-chloro-N-[6-[[(E)-4-(dimethylamino)but-2-enoyl]amino]-7-[(3S)-oxolan-3-yl]oxyquinazolin-4-yl]-4-fluoroanilino)propanedioic acid
Molecular formula	C₂₇H₂₇ClFN₅O₇
Molecular weight	588 g/mol
Exact mass	587.1583
Grade	Reference Standard
HSN code	38229090
InChIKey	USVQENIYOMXKKQ-CWDCEQMOSA-N
SMILES	CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)N(C3=CC(=C(C=C3)F)Cl)C(C(=O)O)C(=O)O)O[C@H]4CCOC4
PubChem CID	154631181

Physical properties
Physical form	Solid
LogP (XLogP3)	0.9
H-bond donors / acceptors	3 / 12
TPSA	154 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Afatinib Malonic acid Adduct?

The CAS Registry Number of Afatinib Malonic acid Adduct is 2413212-27-6.

What is the molecular formula and molecular weight of Afatinib Malonic acid Adduct?

Afatinib Malonic acid Adduct has the molecular formula C27H27ClFN5O7 and a molecular weight of 588 g/mol. Its IUPAC name is 2-(3-chloro-N-[6-[[(E)-4-(dimethylamino)but-2-enoyl]amino]-7-[(3S)-oxolan-3-yl]oxyquinazolin-4-yl]-4-fluoroanilino)propanedioic acid.

What is Afatinib Malonic acid Adduct used for?

Afatinib Malonic acid Adduct is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Afatinib Malonic acid Adduct can I order?

We supply Afatinib Malonic acid Adduct in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Afatinib Malonic acid Adduct?

Yes. Every lot of Afatinib Malonic acid Adduct is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Afatinib Malonic acid Adduct be shipped internationally?

Yes. We export Afatinib Malonic acid Adduct worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.