N-Nitroso-N-Desmethyl Nintedanib (N-1)

About N-Nitroso-N-Desmethyl Nintedanib (N-1)

N-Nitroso-N-Desmethyl Nintedanib (N-1) is a nitrosamine impurity of Nintedanib carrying the CAS registry number 334951-61-0. With the molecular formula C30H31N5O4, it has a molar mass of 525.6 g/mol. Alternative names: Nintedanib metabolite M3 (m/Z 526) and Nintedanib metabolite BIBF 1053.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Nintedanib, method validation (AMV) and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, N-Nitroso-N-Desmethyl Nintedanib (N-1) is dispatched with a Certificate of Analysis (COA) to destinations worldwide. Stock is available for quick dispatch.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Nintedanib

View every impurity, metabolite and intermediate we list for Nintedanib.

Nintedanib impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitroso-N-Desmethyl Nintedanib (N-1)
Catalogue No.	VQ-006985
CAS Number	334951-61-0
IUPAC name	methyl 2-hydroxy-3-[N-[4-[methyl-(2-piperazin-1-ylacetyl)amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate
Molecular formula	C₃₀H₃₁N₅O₄
Molecular weight	525.6 g/mol
Exact mass	525.2376
Grade	Reference Standard
HSN code	38229090
InChIKey	DHQZZWWAHZVLDA-UHFFFAOYSA-N
SMILES	CN(C1=CC=C(C=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)OC)O)C(=O)CN5CCNCC5
PubChem CID	135837936

Physical properties
Physical form	Solid
LogP (XLogP3)	3.8
H-bond donors / acceptors	3 / 7
TPSA	110 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitroso-N-Desmethyl Nintedanib (N-1)?

The CAS Registry Number of N-Nitroso-N-Desmethyl Nintedanib (N-1) is 334951-61-0. It is also known as Nintedanib metabolite M3 (m/Z 526), Nintedanib metabolite BIBF 1053.

What is the molecular formula and molecular weight of N-Nitroso-N-Desmethyl Nintedanib (N-1)?

N-Nitroso-N-Desmethyl Nintedanib (N-1) has the molecular formula C30H31N5O4 and a molecular weight of 525.6 g/mol. Its IUPAC name is methyl 2-hydroxy-3-[N-[4-[methyl-(2-piperazin-1-ylacetyl)amino]phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate.

What is N-Nitroso-N-Desmethyl Nintedanib (N-1) used for?

N-Nitroso-N-Desmethyl Nintedanib (N-1) is supplied as a characterised reference material related to Nintedanib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitroso-N-Desmethyl Nintedanib (N-1) can I order?

We supply N-Nitroso-N-Desmethyl Nintedanib (N-1) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitroso-N-Desmethyl Nintedanib (N-1)?

Yes. Every lot of N-Nitroso-N-Desmethyl Nintedanib (N-1) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitroso-N-Desmethyl Nintedanib (N-1) be shipped internationally?

Yes. We export N-Nitroso-N-Desmethyl Nintedanib (N-1) worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.