Tofacitinib Impurity E

Name: Tofacitinib Impurity E
Brand: Vaqora Chemicals
SKU: VQ-006045

About Tofacitinib Impurity E

Listed under CAS 477600-70-7, Tofacitinib Impurity E is an impurity of Tofacitinib available from Vaqora Chemicals. The compound has the formula C14H22N2, corresponding to a molecular weight of 218.34 g/mol. Systematically, it is named (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine. Alternative names: cis-1-Benzyl-N,4-dimethylpiperidin-3-amine and Tofacitinib Related Impurity 7.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Danger” with 4 hazard statements. Review the Safety Data Sheet before use.

As a characterised impurity of Tofacitinib, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

We offer Tofacitinib Impurity E in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide. Stock is available for quick dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Tofacitinib

View every impurity, metabolite and intermediate we list for Tofacitinib.

Tofacitinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Tofacitinib Impurity E
Catalogue No.	VQ-006045
CAS Number	477600-70-7
Other CAS	1062580-52-2
IUPAC name	(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine
Molecular formula	C₁₄H₂₂N₂
Molecular weight	218.34 g/mol
Exact mass	218.1783
Grade	Reference Standard
HSN code	38229090
InChIKey	NVKDDQBZODSEIN-OCCSQVGLSA-N
SMILES	C[C@@H]1CCN(C[C@@H]1NC)CC2=CC=CC=C2
PubChem CID	44630604

Physical properties
Physical form	Solid
LogP (XLogP3)	2.3
H-bond donors / acceptors	1 / 2
TPSA	15.3 Å²
Synonyms	(3R,4R)-1-Benzyl-N-methyl-4-methylpiperidin-3-amine, (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine, cis-1-Benzyl-N,4-dimethylpiperidin-3-amine, (3R,4R)-N,4-Dimethyl-1-benzyl-3-piperidinamine, (3R,4R)-1-benzyl-N,4-dimethyl-piperidin-3-amine, rel-((3S,4S)-1-Benzyl-N,4-dimethylpiperidin-3-amine), Tofacitinib Related Impurity 7, CS-B0451, (3R,4R)-1-benzyl-N,4-dimethyl-3-piperidinamine, 1-Benzyl-N,4-dimethylpiperidin-3-amine, (3R,4R)-, (3R,4R)-(1-Benzyl-4-methylpiperidin-3-yl)-methylamine, (3R,4R)-1-Benzyl-3-(methylamino)-4-methylpiperidine

Safety & hazard information (GHS)

Corrosive

Harmful / irritant

Signal word: Danger

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P354 + P338, P317, P319, P321, P330, P332 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Tofacitinib Impurity E?

The CAS Registry Number of Tofacitinib Impurity E is 477600-70-7. It is also known as (3R,4R)-1-Benzyl-N-methyl-4-methylpiperidin-3-amine, (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine, cis-1-Benzyl-N,4-dimethylpiperidin-3-amine.

What is the molecular formula and molecular weight of Tofacitinib Impurity E?

Tofacitinib Impurity E has the molecular formula C14H22N2 and a molecular weight of 218.34 g/mol. Its IUPAC name is (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine.

What is Tofacitinib Impurity E used for?

Tofacitinib Impurity E is supplied as a characterised reference material related to Tofacitinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Tofacitinib Impurity E can I order?

We supply Tofacitinib Impurity E in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Tofacitinib Impurity E?

Yes. Every lot of Tofacitinib Impurity E is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Tofacitinib Impurity E be shipped internationally?

Yes. Tofacitinib Impurity E is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.