Estradiol hemihydrate EP Impurity B

Name: Estradiol hemihydrate EP Impurity B
Brand: Vaqora Chemicals
SKU: VQ-022576

About Estradiol hemihydrate EP Impurity B

Estradiol hemihydrate EP Impurity B is a pharmacopeial impurity of Estradiol carrying the CAS registry number 57-91-0. With the molecular formula C18H24O2, it has a molar mass of 272.4 g/mol. Its systematic (IUPAC) name is (8R,9S,13S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol. Common synonyms include 17-Alpha-Estradiol and Ethinylestradiol - Impurity L.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Estradiol to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Estradiol hemihydrate EP Impurity B in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Estradiol

View every impurity, metabolite and intermediate we list for Estradiol.

Estradiol impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Estradiol hemihydrate EP Impurity B
Catalogue No.	VQ-022576
CAS Number	57-91-0
IUPAC name	(8R,9S,13S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
Molecular formula	C₁₈H₂₄O₂
Molecular weight	272.4 g/mol
Exact mass	272.1776
Grade	Reference Standard
HSN code	38229090
InChIKey	VOXZDWNPVJITMN-SFFUCWETSA-N
SMILES	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@H]2O)CCC4=C3C=CC(=C4)O
PubChem CID	68570

Physical properties
Physical form	Solid
LogP (XLogP3)	4
H-bond donors / acceptors	2 / 2
TPSA	40.5 Å²
Synonyms	17-Alpha-Estradiol, Ethinylestradiol - Impurity L, 17α-Estradiol, Estriol EP Impurity J, Ethinylestradiol EP Impurity L, Estradiol Hemihydrate - Impurity B, Estriol - Impurity J, 17alpha-Estradiol, alpha-Estradiol, 17a-estradiol, Estradiol-17alpha

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H350May cause cancer
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P263, P264, P270, P280, P318, P319, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Estradiol hemihydrate EP Impurity B?

The CAS Registry Number of Estradiol hemihydrate EP Impurity B is 57-91-0. It is also known as 17-Alpha-Estradiol, Ethinylestradiol - Impurity L, 17α-Estradiol.

What is the molecular formula and molecular weight of Estradiol hemihydrate EP Impurity B?

Estradiol hemihydrate EP Impurity B has the molecular formula C18H24O2 and a molecular weight of 272.4 g/mol. Its IUPAC name is (8R,9S,13S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol.

What is Estradiol hemihydrate EP Impurity B used for?

Estradiol hemihydrate EP Impurity B is supplied as a characterised reference material related to Estradiol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Estradiol hemihydrate EP Impurity B can I order?

We supply Estradiol hemihydrate EP Impurity B in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Estradiol hemihydrate EP Impurity B?

Yes. Every lot of Estradiol hemihydrate EP Impurity B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Estradiol hemihydrate EP Impurity B be shipped internationally?

Yes. Estradiol hemihydrate EP Impurity B is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.