Hydrochlorothiazide EP Impurity A

About Hydrochlorothiazide EP Impurity A

Hydrochlorothiazide EP Impurity A is a pharmacopeial impurity of Hydrochlorothiazide carrying the CAS registry number 58-94-6. Formula C7H6ClN3O4S2, molecular weight 295.7 g/mol. The IUPAC name is 6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide. It is also known as Chlorothiazide or Hydrochlorothiazide - Impurity A.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a characterised impurity of Hydrochlorothiazide, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Hydrochlorothiazide

View every impurity, metabolite and intermediate we list for Hydrochlorothiazide.

Hydrochlorothiazide impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Hydrochlorothiazide EP Impurity A
Catalogue No.	VQ-022149
CAS Number	58-94-6
IUPAC name	6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Molecular formula	C₇H₆ClN₃O₄S₂
Molecular weight	295.7 g/mol
Exact mass	294.9488
Grade	Reference Standard
HSN code	38229090
InChIKey	JBMKAUGHUNFTOL-UHFFFAOYSA-N
SMILES	C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2
PubChem CID	2720

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.2
H-bond donors / acceptors	2 / 6
TPSA	135 Å²
Synonyms	Chlorothiazide, Hydrochlorothiazide - Impurity A, Chlorthiazide, Chlotride, Chlorosal, Clotride, Diuresal, Warduzide, Alurene, Diurite, Saluric, Neo-Dema

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements: P233, P260, P261, P271, P272, P280, P284, P302 + P352, P304 + P340, P321, P333 + P317, P342 + P316, P362 + P364, P403, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Hydrochlorothiazide EP Impurity A?

The CAS Registry Number of Hydrochlorothiazide EP Impurity A is 58-94-6. It is also known as Chlorothiazide, Hydrochlorothiazide - Impurity A, Chlorthiazide.

What is the molecular formula and molecular weight of Hydrochlorothiazide EP Impurity A?

Hydrochlorothiazide EP Impurity A has the molecular formula C7H6ClN3O4S2 and a molecular weight of 295.7 g/mol. Its IUPAC name is 6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide.

What is Hydrochlorothiazide EP Impurity A used for?

Hydrochlorothiazide EP Impurity A is supplied as a characterised reference material related to Hydrochlorothiazide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Hydrochlorothiazide EP Impurity A can I order?

We supply Hydrochlorothiazide EP Impurity A in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Hydrochlorothiazide EP Impurity A?

Yes. Every lot of Hydrochlorothiazide EP Impurity A is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Hydrochlorothiazide EP Impurity A be shipped internationally?

Yes. Hydrochlorothiazide EP Impurity A is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.