Diethyl

Name: Diethyl
Brand: Vaqora Chemicals
SKU: VQ-021448

About Diethyl

Diethyl is an impurity of Afatinib carrying the CAS registry number 618061-76-0. Its molecular formula is C24H27ClFN4O6P and its molecular weight is 552.9 g/mol. Its systematic (IUPAC) name is N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-2-diethoxyphosphorylacetamide.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

As a characterised impurity of Afatinib, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Diethyl in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Diethyl
Catalogue No.	VQ-021448
CAS Number	618061-76-0
IUPAC name	N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-2-diethoxyphosphorylacetamide
Molecular formula	C₂₄H₂₇ClFN₄O₆P
Molecular weight	552.9 g/mol
Exact mass	552.1341
Grade	Reference Standard
HSN code	38229090
InChIKey	FNGRCLBEXKFSST-INIZCTEOSA-N
SMILES	CCOP(=O)(CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4)OCC
PubChem CID	15606393

Physical properties
Physical form	Solid
LogP (XLogP3)	3.9
H-bond donors / acceptors	2 / 10
TPSA	121 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Diethyl?

The CAS Registry Number of Diethyl is 618061-76-0. It is also known as Diethyl (S)-2-Amino-2-oxoethyl Phosphonate Afatinib.

What is the molecular formula and molecular weight of Diethyl?

Diethyl has the molecular formula C24H27ClFN4O6P and a molecular weight of 552.9 g/mol. Its IUPAC name is N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-2-diethoxyphosphorylacetamide.

What is Diethyl used for?

Diethyl is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Diethyl can I order?

We supply Diethyl in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Diethyl?

Yes. Every lot of Diethyl is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Diethyl be shipped internationally?

Yes. We export Diethyl worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.