N-Nitroso Hydrochlorothiazide

Name: N-Nitroso Hydrochlorothiazide
Brand: Vaqora Chemicals
SKU: VQ-006906

About N-Nitroso Hydrochlorothiazide

N-Nitroso Hydrochlorothiazide (CAS 63779-86-2) is a nitrosamine impurity of Hydrochlorothiazide offered by Vaqora Chemicals. The compound has the formula C7H7ClN4O5S2, corresponding to a molecular weight of 326.7 g/mol. The IUPAC name is 6-chloro-4-nitroso-1,1-dioxo-2,3-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide. It is also known as 4-Nitroso Hydrochlorothiazide or 4-Nitrosohydrochlorothiazide.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 3 hazard statements. Review the Safety Data Sheet before use.

Laboratories use this nitrosamine standard to develop and validate highly sensitive LC-MS/MS methods, to confirm limits of detection and to document nitrosamine risk assessments in regulatory submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies N-Nitroso Hydrochlorothiazide in 10 mg, 25 mg and 50 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide. Stock is available for quick dispatch.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Hydrochlorothiazide

View every impurity, metabolite and intermediate we list for Hydrochlorothiazide.

Hydrochlorothiazide impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitroso Hydrochlorothiazide
Catalogue No.	VQ-006906
CAS Number	63779-86-2
IUPAC name	6-chloro-4-nitroso-1,1-dioxo-2,3-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Molecular formula	C₇H₇ClN₄O₅S₂
Molecular weight	326.7 g/mol
Exact mass	325.9546
Grade	Reference Standard
HSN code	38229090
InChIKey	QJNIRHJVSXLTEW-UHFFFAOYSA-N
SMILES	C1NS(=O)(=O)C2=CC(=C(C=C2N1N=O)Cl)S(=O)(=O)N
PubChem CID	3047617

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.2
H-bond donors / acceptors	2 / 9
TPSA	156 Å²
Synonyms	6-Chloro-4-nitroso-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide, 4-Nitroso Hydrochlorothiazide, 4-Nitrosohydrochlorothiazide, 4-Nitroso-hct, 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-4-nitroso-, 1,1-dioxide, N-Nitroso-hydrochlorothiazide, N-?Nitroso Hydrochlorothiazide, N-nitrosohydrochlorothiazide, N-Nitroso-Hydrochlorothiazide(Nhctz)

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H341Suspected of causing genetic defects
H351Suspected of causing cancer

Precautionary statements: P203, P264, P270, P280, P301 + P317, P318, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitroso Hydrochlorothiazide?

The CAS Registry Number of N-Nitroso Hydrochlorothiazide is 63779-86-2. It is also known as 6-Chloro-4-nitroso-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide, 4-Nitroso Hydrochlorothiazide, 4-Nitrosohydrochlorothiazide.

What is the molecular formula and molecular weight of N-Nitroso Hydrochlorothiazide?

N-Nitroso Hydrochlorothiazide has the molecular formula C7H7ClN4O5S2 and a molecular weight of 326.7 g/mol. Its IUPAC name is 6-chloro-4-nitroso-1,1-dioxo-2,3-dihydro-1lambda6,2,4-benzothiadiazine-7-sulfonamide.

What is N-Nitroso Hydrochlorothiazide used for?

N-Nitroso Hydrochlorothiazide is supplied as a characterised reference material related to Hydrochlorothiazide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitroso Hydrochlorothiazide can I order?

We supply N-Nitroso Hydrochlorothiazide in Reference Standard grade, in 10 mg, 25 mg, 50 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitroso Hydrochlorothiazide?

Yes. Every lot of N-Nitroso Hydrochlorothiazide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitroso Hydrochlorothiazide be shipped internationally?

Yes. N-Nitroso Hydrochlorothiazide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.