Methyl-1-Acetyl-2-oxoindoline-6-carboxylate 676326-36-6

Name: Methyl-1-Acetyl-2-oxoindoline-6-carboxylate
Brand: Vaqora Chemicals
SKU: VQ-027272

About Methyl-1-Acetyl-2-oxoindoline-6-carboxylate

Methyl-1-Acetyl-2-oxoindoline-6-carboxylate (CAS 676326-36-6) is an impurity of Nintedanib offered by Vaqora Chemicals. With the molecular formula C12H11NO4, it has a molar mass of 233.22 g/mol. The IUPAC name is methyl 1-acetyl-2-oxo-3H-indole-6-carboxylate. Alternative names: Nintedanib-002 and CS-M2961.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

This Nintedanib impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Methyl-1-Acetyl-2-oxoindoline-6-carboxylate is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Nintedanib

View every impurity, metabolite and intermediate we list for Nintedanib.

Nintedanib impurities

Specifications & identifiers

Chemical identifiers
Product name	Methyl-1-Acetyl-2-oxoindoline-6-carboxylate
Catalogue No.	VQ-027272
CAS Number	676326-36-6
IUPAC name	methyl 1-acetyl-2-oxo-3H-indole-6-carboxylate
Molecular formula	C₁₂H₁₁NO₄
Molecular weight	233.22 g/mol
Exact mass	233.0688
Grade	Reference Standard
HSN code	38229090
InChIKey	QIMXPFXIAXDPBS-UHFFFAOYSA-N
SMILES	CC(=O)N1C(=O)CC2=C1C=C(C=C2)C(=O)OC
PubChem CID	44191304

Physical properties
Physical form	Solid
LogP (XLogP3)	0.6
H-bond donors / acceptors	0 / 4
TPSA	63.7 Å²
Synonyms	1H-Indole-6-carboxylic acid, 1-acetyl-2,3-dihydro-2-oxo-, methyl ester, Methyl 1-acetyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylate, Methyl 1-acetyl-2,3-dihydro-2-oxo-1H-indole-6-carboxylate, 1-Acetyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester, Nintedanib-002, CS-M2961, 1-Acetyl-2,3-dihydro-2-oxo-1H-indole-6-carboxylic acid methyl ester, 1-acetyl-6-methoxycarbonyl-2-indolinone, methyl-1-acetyl2-oxoindole-6-carboxylate

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H341Suspected of causing genetic defects

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P318, P321, P330, P332 + P317, P337 + P317, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Methyl-1-Acetyl-2-oxoindoline-6-carboxylate?

The CAS Registry Number of Methyl-1-Acetyl-2-oxoindoline-6-carboxylate is 676326-36-6. It is also known as 1H-Indole-6-carboxylic acid, 1-acetyl-2,3-dihydro-2-oxo-, methyl ester, Methyl 1-acetyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylate, Methyl 1-acetyl-2,3-dihydro-2-oxo-1H-indole-6-carboxylate.

What is the molecular formula and molecular weight of Methyl-1-Acetyl-2-oxoindoline-6-carboxylate?

Methyl-1-Acetyl-2-oxoindoline-6-carboxylate has the molecular formula C12H11NO4 and a molecular weight of 233.22 g/mol. Its IUPAC name is methyl 1-acetyl-2-oxo-3H-indole-6-carboxylate.

What is Methyl-1-Acetyl-2-oxoindoline-6-carboxylate used for?

Methyl-1-Acetyl-2-oxoindoline-6-carboxylate is supplied as a characterised reference material related to Nintedanib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Methyl-1-Acetyl-2-oxoindoline-6-carboxylate can I order?

We supply Methyl-1-Acetyl-2-oxoindoline-6-carboxylate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methyl-1-Acetyl-2-oxoindoline-6-carboxylate?

Yes. Every lot of Methyl-1-Acetyl-2-oxoindoline-6-carboxylate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methyl-1-Acetyl-2-oxoindoline-6-carboxylate be shipped internationally?

Yes. Methyl-1-Acetyl-2-oxoindoline-6-carboxylate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.