N-Nitroso Aprepitant Impurity 4

About N-Nitroso Aprepitant Impurity 4

N-Nitroso Aprepitant Impurity 4 is a nitrosamine impurity of Aprepitant carrying the CAS registry number 77817-40-4 at a purity of 99%. With the molecular formula C9H12N2O2, it has a molar mass of 180.2 g/mol. The IUPAC name is N-benzyl-N-(2-hydroxyethyl)nitrous amide. Alternative names: 2-[Nitroso(phenylmethyl)amino]ethanol and 2-(N-Nitroso-N-benzylamino)ethanol.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

It is used as a reference standard for trace-level detection and quantitation of nitrosamine impurities by LC-MS/MS or GC-MS, supporting nitrosamine risk assessments for Aprepitant, method validation (AMV) and regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, N-Nitroso Aprepitant Impurity 4 is dispatched with a Certificate of Analysis (COA) to destinations worldwide. Stock is available for quick dispatch.

Typical applications

Nitrosamine risk assessment
Trace LC-MS/MS quantitation
Method validation (AMV)
Regulatory submissions

Industries

Related to Aprepitant

View every impurity, metabolite and intermediate we list for Aprepitant.

Aprepitant impurities

Specifications & identifiers

Chemical identifiers
Product name	N-Nitroso Aprepitant Impurity 4
Catalogue No.	VQ-006876
CAS Number	77817-40-4
IUPAC name	N-benzyl-N-(2-hydroxyethyl)nitrous amide
Molecular formula	C₉H₁₂N₂O₂
Molecular weight	180.2 g/mol
Exact mass	180.0899
Grade	Reference Standard
Purity / assay	99%
HSN code	38229090
InChIKey	YGPDPBGRXOGBLV-UHFFFAOYSA-N
SMILES	C1=CC=C(C=C1)CN(CCO)N=O
PubChem CID	12684761

Physical properties
Physical form	Solid
LogP (XLogP3)	1
H-bond donors / acceptors	1 / 4
TPSA	52.9 Å²
Synonyms	2-[Nitroso(phenylmethyl)amino]ethanol, 2-(N-Nitroso-N-benzylamino)ethanol, 2-[Benzyl(nitroso)amino]ethan-1-ol, Nitroso Nicardipine, Ethanol, 2-[nitroso(phenylmethyl)amino]-

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H341Suspected of causing genetic defects
H350May cause cancer

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of N-Nitroso Aprepitant Impurity 4?

The CAS Registry Number of N-Nitroso Aprepitant Impurity 4 is 77817-40-4. It is also known as 2-[Nitroso(phenylmethyl)amino]ethanol, 2-(N-Nitroso-N-benzylamino)ethanol, 2-[Benzyl(nitroso)amino]ethan-1-ol.

What is the molecular formula and molecular weight of N-Nitroso Aprepitant Impurity 4?

N-Nitroso Aprepitant Impurity 4 has the molecular formula C9H12N2O2 and a molecular weight of 180.2 g/mol. Its IUPAC name is N-benzyl-N-(2-hydroxyethyl)nitrous amide.

What is N-Nitroso Aprepitant Impurity 4 used for?

N-Nitroso Aprepitant Impurity 4 is supplied as a characterised reference material related to Aprepitant. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of N-Nitroso Aprepitant Impurity 4 can I order?

We supply N-Nitroso Aprepitant Impurity 4 in Reference Standard (99%) grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with N-Nitroso Aprepitant Impurity 4?

Yes. Every lot of N-Nitroso Aprepitant Impurity 4 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can N-Nitroso Aprepitant Impurity 4 be shipped internationally?

Yes. N-Nitroso Aprepitant Impurity 4 is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.