trans-4-Dimethylaminocrotonic acid hydrochlor… 848133-35-7

About trans-4-Dimethylaminocrotonic acid hydrochloride

trans-4-Dimethylaminocrotonic acid hydrochloride is a process intermediate or related compound of Afatinib carrying the CAS registry number 848133-35-7. With the molecular formula C6H12ClNO2, it has a molar mass of 165.62 g/mol.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

It is a process intermediate or related compound in the synthesis of Afatinib, useful for route development, impurity fate-and-purge studies and analytical method development. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, trans-4-Dimethylaminocrotonic acid hydrochloride is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development
Fine chemical synthesis

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	trans-4-Dimethylaminocrotonic acid hydrochloride
Catalogue No.	VQ-039380
CAS Number	848133-35-7
IUPAC name	(E)-4-(dimethylamino)but-2-enoic acid;hydrochloride
Molecular formula	C₆H₁₂ClNO₂
Molecular weight	165.62 g/mol
Exact mass	165.0557
InChIKey	UUHNQHFOIVLAQX-BJILWQEISA-N
SMILES	CN(C)C/C=C/C(=O)O.Cl
PubChem CID	45358758

Physical properties
Physical form	Solid
H-bond donors / acceptors	2 / 3
TPSA	40.5 Å²
Synonyms	4-(Dimethylamino)-2-butenoic acid hydrochloride, (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride, 2-Butenoic acid, 4-(dimethylamino)-, hydrochloride, (2E)-, (2e)-4-(dimethylamino)-2-butenoic acid hydrochloride, 2-Butenoic acid, 4-(dimethylamino)-, hydrochloride (1:1), (2E)-, (E)-4-(Dimethylamino)But-2-Enoic Acid Hydrochloride, 4-(dimethylamino)but-2-enoic acid hydrochloride, (E)-4-(Dimethylamino)but-2-enoic acid xhydrochloride, (E)-4-(dimethylamino)-2-butenoic acid hydrochloride, (E)-4-(dimethylamino) but-2-enoic acid hydrochloride, (E)-4-(Dimethylamino)-2-butenoic Acid xHydrochloride

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements: P264 + P265, P280, P305 + P351 + P338, P337 + P317

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of trans-4-Dimethylaminocrotonic acid hydrochloride?

The CAS Registry Number of trans-4-Dimethylaminocrotonic acid hydrochloride is 848133-35-7. It is also known as 4-(Dimethylamino)-2-butenoic acid hydrochloride, (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride, 2-Butenoic acid, 4-(dimethylamino)-, hydrochloride, (2E)-.

What is the molecular formula and molecular weight of trans-4-Dimethylaminocrotonic acid hydrochloride?

trans-4-Dimethylaminocrotonic acid hydrochloride has the molecular formula C6H12ClNO2 and a molecular weight of 165.62 g/mol.

What is trans-4-Dimethylaminocrotonic acid hydrochloride used for?

trans-4-Dimethylaminocrotonic acid hydrochloride is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of trans-4-Dimethylaminocrotonic acid hydrochloride can I order?

We supply trans-4-Dimethylaminocrotonic acid hydrochloride, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with trans-4-Dimethylaminocrotonic acid hydrochloride?

Yes. Every lot of trans-4-Dimethylaminocrotonic acid hydrochloride is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can trans-4-Dimethylaminocrotonic acid hydrochloride be shipped internationally?

Yes. trans-4-Dimethylaminocrotonic acid hydrochloride is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.