Cobimetinib

Name: Cobimetinib
Brand: Vaqora Chemicals
SKU: VQ-022255

About Cobimetinib

Cobimetinib (CAS 934660-93-2) is a high-purity reference standard of Cobimetinib offered by Vaqora Chemicals. With the molecular formula C21H21F3IN3O2, it has a molar mass of 531.3 g/mol. The IUPAC name is [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl]methanone. It is also known as GDC-0973 or Cotellic.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

As a reference sample of Cobimetinib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Cobimetinib

View every impurity, metabolite and intermediate we list for Cobimetinib.

Cobimetinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Cobimetinib
Catalogue No.	VQ-022255
CAS Number	934660-93-2
IUPAC name	[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl]methanone
Molecular formula	C₂₁H₂₁F₃IN₃O₂
Molecular weight	531.3 g/mol
Exact mass	531.0631
Grade	Reference Standard
HSN code	38229090
InChIKey	BSMCAPRUBJMWDF-KRWDZBQOSA-N
SMILES	C1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
PubChem CID	16222096

Physical properties
Physical form	Solid
LogP (XLogP3)	3.9
H-bond donors / acceptors	3 / 7
TPSA	64.6 Å²
Synonyms	GDC-0973, Cotellic, GDC 0973, Xl-518, XL 518, MEK Inhibitor GDC-0973, Cobimetinib Butyrate, EX-A673, Cobimetinib (GDC-0973, RG7420)

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Cobimetinib?

The CAS Registry Number of Cobimetinib is 934660-93-2. It is also known as GDC-0973, Cotellic, GDC 0973.

What is the molecular formula and molecular weight of Cobimetinib?

Cobimetinib has the molecular formula C21H21F3IN3O2 and a molecular weight of 531.3 g/mol. Its IUPAC name is [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl]methanone.

What is Cobimetinib used for?

Cobimetinib is supplied as a characterised reference material related to Cobimetinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Cobimetinib can I order?

We supply Cobimetinib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Cobimetinib?

Yes. Every lot of Cobimetinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Cobimetinib be shipped internationally?

Yes. We export Cobimetinib worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.