Impurity reference standards
Ruxolitinib impurities & reference standards
Characterised Ruxolitinib impurities, degradation products and related compounds for analytical method development, validation, QC release and regulatory filings.
51reference materials
1isotope-labelled
COAHPLC · NMR · MS on request
Parent API: Ruxolitinib WS
941678-49-5 · C17H18N6
![(R)-(4-(1-(2-Cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate chemical structure](/media/structures/VONAHXIMKYWQCQ-LJQANCHMSA-N.svg)
(R)-(4-(1-(2-Cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl Pivalate
- CAS
- 1146629-80-2
- Formula
- C23H28N6O2
- MW
- 420.5 g/mol
VQ-033713
![(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanamide chemical structure](/media/structures/JZKNOTYMYVXDNN-CQSZACIVSA-N.svg)
(R)-3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanamide
- CAS
- 2102675-42-1
- Formula
- C17H20N6O
- MW
- 324.4 g/mol
VQ-027792
(R)-3-Cyclopentyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile
- CAS
- 1146629-84-6
- Formula
- C17H26BN3O2
- MW
- 315.2 g/mol
VQ-042046
![(R)-3-Cyclopentyl-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile chemical structure](/media/structures/QHQSWYIJDFMBNE-OAQYLSRUSA-N.svg)
(R)-3-Cyclopentyl-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile
- CAS
- 941685-40-1
- Formula
- C23H32N6OSi
- MW
- 436.6 g/mol
VQ-033710
![(R)-3-Cyclopentyl-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile (2S,3S)-2,3-bis(benzoyloxy)succinate chemical structure](/media/structures/QSAALLKTEBWYGD-FFLVPEHISA-N.svg)
(R)-3-Cyclopentyl-3-(4-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile (2S,3S)-2,3-bis(benzoyloxy)succinate
- CAS
- 1236033-04-7
- Formula
- C41H46N6O9Si
- MW
- 794.9 g/mol
VQ-033709
(S)-3-(4-Bromo-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
- CAS
- 2183286-19-1
- Formula
- C11H14BrN3
- MW
- 268.15 g/mol
VQ-033712
![3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanoic Acid chemical structure](/media/structures/IPENMCZAZMYXFD-UHFFFAOYSA-N.svg)
3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanoic Acid
- CAS
- 3016399-21-3
- Formula
- C17H19N5O2
- MW
- 325.4 g/mol
VQ-027952
4 1 2 Cyano 1 cyclopentylethyl 1h pyrazol 4 yl 7h pyrrolo 2 3 d pyrimidin 7 yl methyl pivalate
- CAS
- 1236033-05-8
- Formula
- C23H28N6O2
- MW
- 420.5 g/mol
VQ-042045
Ruxolitinib 7-Hydroxymethyl Impurity (R- Isomer)
- CAS
- 1236033-03-6
- Formula
- C18H20N6O
- MW
- 336.4 g/mol
In stock
Ruxolitinib Impurity 11 (Diastereomeric Mixture)
- CAS
- 1092973-96-0
- Formula
- C17H16N6O
- MW
- 320.3 g/mol
VQ-005844
Ruxolitinib M18 Metabolite (Diastereomeric Mixture)
- CAS
- 1092973-95-9
- Formula
- C17H18N6O
- MW
- 322.4 g/mol
In stock
Ruxolitinib Metabolite 1 (Diastereomeric Mixture)
- CAS
- 1092973-94-8
- Formula
- C17H18N6O
- MW
- 322.4 g/mol
In stock
Ruxolitinib Pyrazole Deazapurine Pyrimidine Impurity
- CAS
- 941685-27-4
- Formula
- C15H21N5OSi
- MW
- 315.45 g/mol
VQ-005850
FAQs — Ruxolitinib impurities
Which Ruxolitinib impurities do you supply?
We list 51 Ruxolitinib-related reference materials, including process impurities, degradation products, stable-isotope-labelled standards and related compounds. Each is supplied with a COA, and characterisation data (HPLC, 1H-NMR, MS, IR) can be provided on request.
What are Ruxolitinib impurity standards used for?
They are used for analytical method development and validation, impurity identification and quantification, forced-degradation and stability studies, and to support ANDA, DMF and other regulatory submissions under ICH Q3A/Q3B (and ICH M7 for mutagenic impurities).
Can you synthesise a Ruxolitinib impurity that is not listed?
Yes. Our custom synthesis service can prepare and characterise unlisted impurities, metabolites and labelled analogues from milligram to gram scale. Share the structure or name and required quantity for a quotation.
Request Ruxolitinib impurity standards
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