1R,2S,3S Aprepitant

Name: 1R,2S,3S Aprepitant
Brand: Vaqora Chemicals
SKU: VQ-024341

About 1R,2S,3S Aprepitant

Listed under CAS 172822-28-5, 1R,2S,3S Aprepitant is an impurity of Aprepitant available from Vaqora Chemicals. Formula C23H21F7N4O3, molecular weight 534.4 g/mol. Alternative names: Aprepitant (R,S,S)-Isomer and (2S,3S,1'R)-Aprepitant.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Good laboratory practice and suitable PPE are recommended during handling.

As a characterised impurity of Aprepitant, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer 1R,2S,3S Aprepitant in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Aprepitant

View every impurity, metabolite and intermediate we list for Aprepitant.

Aprepitant impurities

Specifications & identifiers

Chemical identifiers
Product name	1R,2S,3S Aprepitant
Catalogue No.	VQ-024341
CAS Number	172822-28-5
IUPAC name	3-[[(2S,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,4-dihydro-1,2,4-triazol-5-one
Molecular formula	C₂₃H₂₁F₇N₄O₃
Molecular weight	534.4 g/mol
Exact mass	534.1502
Grade	Reference Standard
HSN code	38229090
InChIKey	ATALOFNDEOCMKK-CFGAKRJMSA-N
SMILES	C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@H]2[C@@H](N(CCO2)CC3=NNC(=O)N3)C4=CC=C(C=C4)F
PubChem CID	135506334

Physical properties
Physical form	Solid
LogP (XLogP3)	4.2
H-bond donors / acceptors	2 / 12
TPSA	75.2 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 1R,2S,3S Aprepitant?

The CAS Registry Number of 1R,2S,3S Aprepitant is 172822-28-5. It is also known as Aprepitant (R,S,S)-Isomer, (2S,3S,1'R)-Aprepitant, Aprepitant, (2S,3S,1'R)-.

What is the molecular formula and molecular weight of 1R,2S,3S Aprepitant?

1R,2S,3S Aprepitant has the molecular formula C23H21F7N4O3 and a molecular weight of 534.4 g/mol. Its IUPAC name is 3-[[(2S,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,4-dihydro-1,2,4-triazol-5-one.

What is 1R,2S,3S Aprepitant used for?

1R,2S,3S Aprepitant is supplied as a characterised reference material related to Aprepitant. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 1R,2S,3S Aprepitant can I order?

We supply 1R,2S,3S Aprepitant in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 1R,2S,3S Aprepitant?

Yes. Every lot of 1R,2S,3S Aprepitant is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 1R,2S,3S Aprepitant be shipped internationally?

Yes. We export 1R,2S,3S Aprepitant worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.