(4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl… 52980-66-2

Name: (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid
Brand: Vaqora Chemicals
SKU: VQ-038365

About (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid

Listed under CAS 52980-66-2, (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid is an impurity of Methotrexate available from Vaqora Chemicals. With the molecular formula C20H22N8O5, it has a molar mass of 454.4 g/mol. Systematically, it is named (2S)-2-[[4-[(2,4-diaminopteridin-7-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid. It is also known as 7-Methotrexate or 7-Mtx.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Handle it with standard laboratory precautions and appropriate personal protective equipment.

This Methotrexate impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Methotrexate

View every impurity, metabolite and intermediate we list for Methotrexate.

Methotrexate impurities

Specifications & identifiers

Chemical identifiers
Product name	(4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid
Catalogue No.	VQ-038365
CAS Number	52980-66-2
IUPAC name	(2S)-2-[[4-[(2,4-diaminopteridin-7-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
Molecular formula	C₂₀H₂₂N₈O₅
Molecular weight	454.4 g/mol
Exact mass	454.1713
Grade	Reference Standard
HSN code	38229090
InChIKey	UUVPYTIBUIBXTJ-ZDUSSCGKSA-N
SMILES	CN(CC1=CN=C2C(=NC(=NC2=N1)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
PubChem CID	3040815

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.8
H-bond donors / acceptors	5 / 12
TPSA	211 Å²
Synonyms	7-Methotrexate, N-(4-(((2,4-Diamino-7-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid, 7-Mtx, N-(4-(((2,4-Diamino-7-pteridinyl)methyl)methylamino)benzoyl)-DL-glutamic acid, N-(p-(((2,4-Diamino-7-pteridinyl)methyl)methylamino)benzoyl)-DL-glutamic acid, Glutamic acid, N-(p-(((2,4-diamino-7-pteridinyl)methyl)methylamino)benzoyl)-, DL-, Glutamic acid, N-(p-(((2,4-diamino-7-pteridinyl)methyl)methylamino)benzoyl)-, L-, N-(4-(((2,4-Diamino-7-pteridyl)methyl)-N(sup 10)-methylamino)benzoyl)glutamic acid, DL-Glutamic acid, N-(4-(((2,4-diamino-7-pteridinyl)methyl)methylamino)benzoyl)-, L-Glutamic acid, N-(4-(((2,4-diamino-7-pteridinyl)methyl)methylamino)benzoyl)-, N-[p-[[(2,4-diaminopteridin-7-yl)methyl ]methylamino]benzoyl ]-l-glutamic acid

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid?

The CAS Registry Number of (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid is 52980-66-2. It is also known as 7-Methotrexate, N-(4-(((2,4-Diamino-7-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid, 7-Mtx.

What is the molecular formula and molecular weight of (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid?

(4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid has the molecular formula C20H22N8O5 and a molecular weight of 454.4 g/mol. Its IUPAC name is (2S)-2-[[4-[(2,4-diaminopteridin-7-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid.

What is (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid used for?

(4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid is supplied as a characterised reference material related to Methotrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid can I order?

We supply (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid?

Yes. Every lot of (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid be shipped internationally?

Yes. We export (4-(((2,4-Diaminopteridin-7-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.