Erlotinib

Name: Erlotinib
Brand: Vaqora Chemicals
SKU: VQ-004213

About Erlotinib

Vaqora Chemicals supplies Erlotinib in IP/BP/USP grade, an anticancer API registered under CAS number 183321-74-6, specified at ≥99% purity. With the molecular formula C22H23N3O4, it has a molar mass of 393.4 g/mol. Its systematic (IUPAC) name is N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine. Common synonyms include Erlotinib free base and Erlotinib Base.

In its supplied form it is a white powder. Store sealed in a dry, well-ventilated location away from incompatible materials. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

This API belongs to our oncology APIs portfolio and is supplied to IP/BP/USP specifications for formulators, contract manufacturers and generic drug developers. Our customers for this product work in pharmaceutical manufacturing.

We offer Erlotinib in 1 kg, 5 kg and 25 kg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Polymer & resin production
Pharmaceutical formulation

Industries

Related to Erlotinib

View every impurity, metabolite and intermediate we list for Erlotinib.

Erlotinib impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Erlotinib
Catalogue No.	VQ-004213
CAS Number	183321-74-6
IUPAC name	N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
Molecular formula	C₂₂H₂₃N₃O₄
Molecular weight	393.4 g/mol
Exact mass	393.1689
Grade	IP/BP/USP
Purity / assay	≥99%
HSN code	2933
InChIKey	AAKJLRGGTJKAMG-UHFFFAOYSA-N
SMILES	COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC
PubChem CID	176870

Physical properties
Physical form	Powder
Appearance	White powder
LogP (XLogP3)	3.3
H-bond donors / acceptors	1 / 7
TPSA	74.7 Å²
Synonyms	4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine, (6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine, N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, Erlotinib free base, 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline, Erlotinib Base, Kinome_3317, Erlotinib, Free Base, Erlotinib (INN), Erlotinib(Tarceva), 183321-74-6 (free base)

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H351Suspected of causing cancer
H411Toxic to aquatic life with long lasting effects
H413May cause long lasting harmful effects to aquatic life

Precautionary statements: P203, P264, P270, P273, P280, P301 + P317, P318, P330, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Other grades of CAS 183321-74-6

Reference Standard

Erlotinib WS

CAS: 183321-74-6
Formula: C₂₂H₂₃N₃O₄
MW: 393.4 g/mol

In stock

Cell Culture

Erlotinib, cell culture tested

CAS: 183321-74-6
Formula: C₂₂H₂₃N₃O₄
MW: 393.4 g/mol

VQ-046460

Frequently asked questions

What is the CAS number of Erlotinib?

The CAS Registry Number of Erlotinib is 183321-74-6. It is also known as 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-, [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine, (6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl)-(3-ethynyl-phenyl)-amine.

What is the molecular formula and molecular weight of Erlotinib?

Erlotinib has the molecular formula C22H23N3O4 and a molecular weight of 393.4 g/mol. Its IUPAC name is N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine.

What is Erlotinib used for?

Erlotinib is supplied as a characterised reference material related to Erlotinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Erlotinib can I order?

We supply Erlotinib in IP/BP/USP (≥99%) grade, in 1 kg, 5 kg, 25 kg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Erlotinib?

Yes. Every lot of Erlotinib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Erlotinib be shipped internationally?

Yes. Erlotinib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.