Glibenclamide

Name: Glibenclamide
Brand: Vaqora Chemicals
SKU: VQ-004130

About Glibenclamide

Glibenclamide is a metabolic / hormonal API (IP/BP/USP grade) carrying the CAS registry number 10238-21-8 with a typical assay of 99.0%. With the molecular formula C23H28ClN3O5S, it has a molar mass of 494.0 g/mol. Its systematic (IUPAC) name is 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide. Common synonyms include glyburide and Semi-daonil.

The material typically appears as a white or almost white crystalline powder.(Results:Conforms). Store sealed in a dry, well-ventilated location away from incompatible materials. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As an active pharmaceutical ingredient within our antidiabetic, hormone and metabolic APIs range, it is offered in IP/BP/USP grade for formulation development, generic drug programmes and commercial manufacturing. Typical end-use sectors are pharmaceutical manufacturing.

Standard pack sizes are 1 kg, 5 kg and 25 kg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmaceutical formulation
Generic drug development

Industries

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Glibenclamide
Catalogue No.	VQ-004130
CAS Number	10238-21-8
IUPAC name	5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
Molecular formula	C₂₃H₂₈ClN₃O₅S
Molecular weight	494 g/mol
Exact mass	493.1438
Grade	IP/BP/USP
Purity / assay	99.0%
HSN code	2933
InChIKey	ZNNLBTZKUZBEKO-UHFFFAOYSA-N
SMILES	COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
PubChem CID	3488

Physical properties
Physical form	Powder
Appearance	White or almost white crystalline powder.(Results:Conforms)
LogP (XLogP3)	4.8
H-bond donors / acceptors	3 / 5
TPSA	122 Å²
Synonyms	glyburide, Semi-daonil, Glyburide (micronized), HB 419, 1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea, Diabetamide 5, Diabetamide 2.5, 5-chloro-N-[2-(4-{[(cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-methoxybenzamide, N-(4-(beta-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff, HB 420, Glynase Prestab, 5-chloro-N-(2-(4-(((cyclohexylcarbamoyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H413May cause long lasting harmful effects to aquatic life

Precautionary statements: P264, P270, P273, P301 + P317, P330, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Glibenclamide?

The CAS Registry Number of Glibenclamide is 10238-21-8. It is also known as glyburide, Semi-daonil, Glyburide (micronized).

What is the molecular formula and molecular weight of Glibenclamide?

Glibenclamide has the molecular formula C23H28ClN3O5S and a molecular weight of 494 g/mol. Its IUPAC name is 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide.

Which grade and pack sizes of Glibenclamide can I order?

We supply Glibenclamide in IP/BP/USP (99.0%) grade, in 1 kg, 5 kg, 25 kg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Glibenclamide?

Yes. Every lot of Glibenclamide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Glibenclamide be shipped internationally?

Yes. Glibenclamide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.