Methotrexate Dimethylamide

Name: Methotrexate Dimethylamide
Brand: Vaqora Chemicals
SKU: VQ-013546

About Methotrexate Dimethylamide

Methotrexate Dimethylamide (CAS 71074-44-7) is a process intermediate or related compound of Methotrexate offered by Vaqora Chemicals. The compound has the formula C22H27N9O4, corresponding to a molecular weight of 481.5 g/mol. Systematically, it is named (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-(dimethylamino)-5-oxopentanoic acid. It is also known as Methotrexate N,N-dimethylamide or Methotrexate-gamma-dimethylamide.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 6 hazard statements. Review the Safety Data Sheet before use.

It is a process intermediate or related compound in the synthesis of Methotrexate, useful for route development, impurity fate-and-purge studies and analytical method development. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Methotrexate Dimethylamide is dispatched with a Certificate of Analysis (COA) to destinations worldwide. Stock is available for quick dispatch.

Typical applications

API route development
Impurity fate & purge studies
Analytical method development

Industries

Related to Methotrexate

View every impurity, metabolite and intermediate we list for Methotrexate.

Methotrexate impurities

Specifications & identifiers

Chemical identifiers
Product name	Methotrexate Dimethylamide
Catalogue No.	VQ-013546
CAS Number	71074-44-7
IUPAC name	(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-(dimethylamino)-5-oxopentanoic acid
Molecular formula	C₂₂H₂₇N₉O₄
Molecular weight	481.5 g/mol
Exact mass	481.2186
Grade	Reference Standard
HSN code	2933
InChIKey	BHFZGVOUGIGQGR-HNNXBMFYSA-N
SMILES	CN(C)C(=O)CC[C@@H](C(=O)O)NC(=O)C1=CC=C(C=C1)N(C)CC2=CN=C3C(=N2)C(=NC(=N3)N)N
PubChem CID	100284

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.9
H-bond donors / acceptors	4 / 11
TPSA	194 Å²
Synonyms	Methotrexate N,N-dimethylamide, N2-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-N,N-dimethyl-L-glutamine, Methotrexate-gamma-dimethylamide, Mxt-gamma-dma, Methotrexate Dimethylamide (>90%), Methotrexate Dimethylamide (>85%), L-Glutamine, N2-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-N,N-dimethyl-, N2-(4-(((2,4-Diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-N5,N5-dimethyl-L-glutamine

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Methotrexate Dimethylamide?

The CAS Registry Number of Methotrexate Dimethylamide is 71074-44-7. It is also known as Methotrexate N,N-dimethylamide, N2-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-N,N-dimethyl-L-glutamine, Methotrexate-gamma-dimethylamide.

What is the molecular formula and molecular weight of Methotrexate Dimethylamide?

Methotrexate Dimethylamide has the molecular formula C22H27N9O4 and a molecular weight of 481.5 g/mol. Its IUPAC name is (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-(dimethylamino)-5-oxopentanoic acid.

What is Methotrexate Dimethylamide used for?

Methotrexate Dimethylamide is supplied as a characterised reference material related to Methotrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Methotrexate Dimethylamide can I order?

We supply Methotrexate Dimethylamide in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methotrexate Dimethylamide?

Yes. Every lot of Methotrexate Dimethylamide is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methotrexate Dimethylamide be shipped internationally?

Yes. Methotrexate Dimethylamide is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.