Methotrexate Impurity (Stage-3)

Name: Methotrexate Impurity (Stage-3)
Brand: Vaqora Chemicals
SKU: VQ-005270

About Methotrexate Impurity (Stage-3)

Methotrexate Impurity (Stage-3) (CAS 2378-95-2) is an impurity of Methotrexate offered by Vaqora Chemicals. Formula C17H24N2O5, molecular weight 336.4 g/mol. Its systematic (IUPAC) name is diethyl (2S)-2-[[4-(methylamino)benzoyl]amino]pentanedioate. Alternative names: Diethyl N-(p-N-methylaminobenzoyl)glutamate.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a characterised impurity of Methotrexate, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Methotrexate Impurity (Stage-3) in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide. Stock is available for quick dispatch.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Methotrexate

View every impurity, metabolite and intermediate we list for Methotrexate.

Methotrexate impurities

Specifications & identifiers

Chemical identifiers
Product name	Methotrexate Impurity (Stage-3)
Catalogue No.	VQ-005270
CAS Number	2378-95-2
IUPAC name	diethyl (2S)-2-[[4-(methylamino)benzoyl]amino]pentanedioate
Molecular formula	C₁₇H₂₄N₂O₅
Molecular weight	336.4 g/mol
Exact mass	336.1685
Grade	Reference Standard
HSN code	38229090
InChIKey	WBYNXAAEBPJETG-AWEZNQCLSA-N
SMILES	CCOC(=O)CC[C@@H](C(=O)OCC)NC(=O)C1=CC=C(C=C1)NC
PubChem CID	75413

Physical properties
Physical form	Solid
LogP (XLogP3)	2.1
H-bond donors / acceptors	2 / 6
TPSA	93.7 Å²
Synonyms	N-(4-N-Methylaminobenzoyl)-L-glutamic acid diethyl ester, 1,5-Diethyl N-[4-(methylamino)benzoyl]-L-glutamate, (S)-Diethyl 2-(4-(methylamino)benzamido)pentanedioate, Diethyl N-(p-N-methylaminobenzoyl)glutamate, Diethyl N-[4-(methylamino)benzoyl]-L-glutamate, Diethyl N-(4-(methylamino)benzoyl)-L-glutamate, N-(p-Methylaminobenzoyl)glutamic acid diethyl ester, L-Glutamic acid, N-(4-(methylamino)benzoyl)-, diethyl ester, Glutamic acid, N-(p-(methylamino)benzoyl)-, diethyl ester, L-, L-Glutamic acid, N-(4-(methylamino)benzoyl)-, 1,5-diethyl ester, L-Glutamic acid, N-[4-(methylamino)benzoyl]-, 1,5-diethyl ester, L-Glutamic acid, N-[4-(methylamino)benzoyl]-, diethyl ester

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302+H312+H332Harmful if swallowed, in contact with skin or if inhaled
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
H341Suspected of causing genetic defects
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P261, P264, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P317, P318, P321, P330, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Methotrexate Impurity (Stage-3)?

The CAS Registry Number of Methotrexate Impurity (Stage-3) is 2378-95-2. It is also known as N-(4-N-Methylaminobenzoyl)-L-glutamic acid diethyl ester, 1,5-Diethyl N-[4-(methylamino)benzoyl]-L-glutamate, (S)-Diethyl 2-(4-(methylamino)benzamido)pentanedioate.

What is the molecular formula and molecular weight of Methotrexate Impurity (Stage-3)?

Methotrexate Impurity (Stage-3) has the molecular formula C17H24N2O5 and a molecular weight of 336.4 g/mol. Its IUPAC name is diethyl (2S)-2-[[4-(methylamino)benzoyl]amino]pentanedioate.

What is Methotrexate Impurity (Stage-3) used for?

Methotrexate Impurity (Stage-3) is supplied as a characterised reference material related to Methotrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Methotrexate Impurity (Stage-3) can I order?

We supply Methotrexate Impurity (Stage-3) in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methotrexate Impurity (Stage-3)?

Yes. Every lot of Methotrexate Impurity (Stage-3) is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methotrexate Impurity (Stage-3) be shipped internationally?

Yes. Methotrexate Impurity (Stage-3) is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.