Methotrexate Disodium Salt

Name: Methotrexate Disodium Salt
Brand: Vaqora Chemicals
SKU: VQ-007577

About Methotrexate Disodium Salt

Vaqora Chemicals supplies Methotrexate Disodium Salt, a high-purity reference standard of Methotrexate registered under CAS number 7413-34-5. Its molecular formula is C20H20N8Na2O5 and its molecular weight is 498.4 g/mol. Its systematic (IUPAC) name is disodium, (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate. Common synonyms include Amethopterin sodium and Methotrexate Lederle.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

Laboratories use this Methotrexate standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Methotrexate Disodium Salt is dispatched with a Certificate of Analysis (COA) to destinations worldwide. Stock is available for quick dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Methotrexate

View every impurity, metabolite and intermediate we list for Methotrexate.

Methotrexate impurities

Specifications & identifiers

Chemical identifiers
Product name	Methotrexate Disodium Salt
Catalogue No.	VQ-007577
CAS Number	7413-34-5
IUPAC name	disodium;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate
Molecular formula	C₂₀H₂₀N₈Na₂O₅
Molecular weight	498.4 g/mol
Exact mass	498.1352
Grade	Reference Standard
HSN code	38229090
InChIKey	DASQOOZCTWOQPA-GXKRWWSZSA-L
SMILES	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
PubChem CID	11329481

Physical properties
Physical form	Solid
H-bond donors / acceptors	3 / 12
TPSA	216 Å²
Synonyms	Amethopterin sodium, Methotrexate Lederle, Metoart, Metotrexato Lederle, Sodium methotrexate, N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid Disodium Salt, Disodium methotrexate, Abitrexate, Methotrexate Lpf, Folex Pfs, Mexate-Aq Preserved, Mexate-Aq

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
H340May cause genetic defects
H360May damage fertility or the unborn child

Precautionary statements: P203, P261, P262, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P351 + P338, P316, P318, P319, P321, P330, P332 + P317, P337 + P317, P361 + P364, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Other grades of CAS 7413-34-5

Methotrexate Disodium Salt

CAS: 7413-34-5
Formula: C₂₀H₂₀N₈Na₂O₅
MW: 498.4 g/mol

VQ-046725

Cell Culture

Methotrexate Disodium Salt, cell culture tested

CAS: 7413-34-5
Formula: C₂₀H₂₀N₈Na₂O₅
MW: 498.4 g/mol

VQ-046238

Frequently asked questions

What is the CAS number of Methotrexate Disodium Salt?

The CAS Registry Number of Methotrexate Disodium Salt is 7413-34-5. It is also known as Amethopterin sodium, Methotrexate Lederle, Metoart.

What is the molecular formula and molecular weight of Methotrexate Disodium Salt?

Methotrexate Disodium Salt has the molecular formula C20H20N8Na2O5 and a molecular weight of 498.4 g/mol.

What is Methotrexate Disodium Salt used for?

Methotrexate Disodium Salt is supplied as a characterised reference material related to Methotrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Methotrexate Disodium Salt can I order?

We supply Methotrexate Disodium Salt in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg, 250 mg, 500 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methotrexate Disodium Salt?

Yes. Every lot of Methotrexate Disodium Salt is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methotrexate Disodium Salt be shipped internationally?

Yes. Methotrexate Disodium Salt is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.