Methotrexate EP Impurity F

Name: Methotrexate EP Impurity F
Brand: Vaqora Chemicals
SKU: VQ-023093

About Methotrexate EP Impurity F

Vaqora Chemicals supplies Methotrexate EP Impurity F, a pharmacopeial impurity of Methotrexate registered under CAS number 51865-79-3. The compound has the formula C20H22N8O5, corresponding to a molecular weight of 454.4 g/mol. The IUPAC name is (2R)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid. Alternative names: (R)-Methotrexate and Methotrexate - Impurity F (Freebase).

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. It carries the GHS signal word “Danger” with 7 hazard statements. Review the Safety Data Sheet before use.

Pharmaceutical QC and development laboratories use this impurity standard of Methotrexate to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Methotrexate

View every impurity, metabolite and intermediate we list for Methotrexate.

Methotrexate impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Methotrexate EP Impurity F
Catalogue No.	VQ-023093
CAS Number	51865-79-3
IUPAC name	(2R)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
Molecular formula	C₂₀H₂₂N₈O₅
Molecular weight	454.4 g/mol
Exact mass	454.1713
Grade	Reference Standard
HSN code	38229090
InChIKey	FBOZXECLQNJBKD-CYBMUJFWSA-N
SMILES	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@H](CCC(=O)O)C(=O)O
PubChem CID	72440

Physical properties
Physical form	Solid
LogP (XLogP3)	-1.8
H-bond donors / acceptors	5 / 12
TPSA	211 Å²
Synonyms	(R)-Methotrexate, Methotrexate - Impurity F (Freebase), D-Amethopterin, D-Methotrexate, Methotrexate, (R)-, R-methotrexate, Methotrexate, d-, N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-D-glutamic acid, Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, D-, D-glutamic acid, N-(4-(((2,4-diamino-6-pteridyl)methyl)methylamino)benzoyl)-, D-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, (2R)-2-((4-((2,4-diaminopteridin-6-yl)methyl-methylamino)benzoyl)amino)pentanedioic acid

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H341Suspected of causing genetic defects
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H373May causes damage to organs through prolonged or repeated exposure

Precautionary statements: P203, P260, P264, P264 + P265, P270, P280, P301 + P316, P302 + P352, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Methotrexate EP Impurity F?

The CAS Registry Number of Methotrexate EP Impurity F is 51865-79-3. It is also known as (R)-Methotrexate, Methotrexate - Impurity F (Freebase), D-Amethopterin.

What is the molecular formula and molecular weight of Methotrexate EP Impurity F?

Methotrexate EP Impurity F has the molecular formula C20H22N8O5 and a molecular weight of 454.4 g/mol. Its IUPAC name is (2R)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid.

What is Methotrexate EP Impurity F used for?

Methotrexate EP Impurity F is supplied as a characterised reference material related to Methotrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Methotrexate EP Impurity F can I order?

We supply Methotrexate EP Impurity F in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methotrexate EP Impurity F?

Yes. Every lot of Methotrexate EP Impurity F is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methotrexate EP Impurity F be shipped internationally?

Yes. Methotrexate EP Impurity F is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.