Naproxen EP Impurity B

Name: Naproxen EP Impurity B
Brand: Vaqora Chemicals
SKU: VQ-023210

About Naproxen EP Impurity B

Listed under CAS 89617-86-7, Naproxen EP Impurity B is a pharmacopeial impurity of Naproxen available from Vaqora Chemicals. Formula C14H13ClO3, molecular weight 264.7 g/mol. Its systematic (IUPAC) name is (2S)-2-(5-chloro-6-methoxynaphthalen-2-yl)propanoic acid. Common synonyms include (S)-5-Chloro Naproxen and Naproxen - Impurity B.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a characterised impurity of Naproxen, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Naproxen EP Impurity B in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Naproxen

View every impurity, metabolite and intermediate we list for Naproxen.

Naproxen impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Naproxen EP Impurity B
Catalogue No.	VQ-023210
CAS Number	89617-86-7
IUPAC name	(2S)-2-(5-chloro-6-methoxynaphthalen-2-yl)propanoic acid
Molecular formula	C₁₄H₁₃ClO₃
Molecular weight	264.7 g/mol
Exact mass	264.0553
Grade	Reference Standard
HSN code	38229090
InChIKey	RVVAYDHIVLCPBC-QMMMGPOBSA-N
SMILES	C[C@@H](C1=CC2=C(C=C1)C(=C(C=C2)OC)Cl)C(=O)O
PubChem CID	13075209

Physical properties
Physical form	Solid
LogP (XLogP3)	3.8
H-bond donors / acceptors	1 / 3
TPSA	46.5 Å²
Synonyms	(S)-5-Chloro Naproxen, Naproxen - Impurity B, 5-Chloronaproxen, (S)-, 5-Chloro naproxen, (S)-, 5-Chloro naproxen, (+)-, 2-Naphthaleneacetic acid, 5-chloro-6-methoxy-alpha-methyl-, (alphaS)-, Naproxen impurity B, Naproxen sodium impurity B, (S)-2-(5-Chloro-6-methoxynaphthalen-2-yl)propanoic acid, (S)-5-Chloro-6-Methoxy-, A-Methyl-2-naphthaleneacetic Acid, (2S)-2-(5-Chloro-6-methoxynaphthalen-2-yl)propanoic Acid (5-Chloronaproxen)

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Environmental hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H411Toxic to aquatic life with long lasting effects

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P273, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P391, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Naproxen EP Impurity B?

The CAS Registry Number of Naproxen EP Impurity B is 89617-86-7. It is also known as (S)-5-Chloro Naproxen, Naproxen - Impurity B, 5-Chloronaproxen, (S)-.

What is the molecular formula and molecular weight of Naproxen EP Impurity B?

Naproxen EP Impurity B has the molecular formula C14H13ClO3 and a molecular weight of 264.7 g/mol. Its IUPAC name is (2S)-2-(5-chloro-6-methoxynaphthalen-2-yl)propanoic acid.

What is Naproxen EP Impurity B used for?

Naproxen EP Impurity B is supplied as a characterised reference material related to Naproxen. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Naproxen EP Impurity B can I order?

We supply Naproxen EP Impurity B in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Naproxen EP Impurity B?

Yes. Every lot of Naproxen EP Impurity B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Naproxen EP Impurity B be shipped internationally?

Yes. Naproxen EP Impurity B is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.