Roflumilast

Name: Roflumilast
Brand: Vaqora Chemicals
SKU: VQ-007728

About Roflumilast

Roflumilast (CAS 162401-32-3) is a high-purity reference standard of Roflumilast offered by Vaqora Chemicals. With the molecular formula C17H14Cl2F2N2O3, it has a molar mass of 403.2 g/mol. Its systematic (IUPAC) name is 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide. Alternative names: BY 217 and Daxas.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Roflumilast, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Roflumilast in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide. This item is currently in stock for prompt dispatch.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Roflumilast

View every impurity, metabolite and intermediate we list for Roflumilast.

Roflumilast impurities

Specifications & identifiers

Chemical identifiers
Product name	Roflumilast
Catalogue No.	VQ-007728
CAS Number	162401-32-3
IUPAC name	3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide
Molecular formula	C₁₇H₁₄Cl₂F₂N₂O₃
Molecular weight	403.2 g/mol
Exact mass	402.035
Grade	Reference Standard
HSN code	38229090
InChIKey	MNDBXUUTURYVHR-UHFFFAOYSA-N
SMILES	C1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F
PubChem CID	449193

Physical properties
Physical form	Solid
LogP (XLogP3)	4.6
H-bond donors / acceptors	1 / 6
TPSA	60.5 Å²
Synonyms	BY 217, Daxas, Libertek, Benzamide, 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-, BY-217, ARQ-154 (Roflumilast foam), ARQ-151, 3-cyclopropylmethoxy-4-difluoromethoxy-N-(3,5-di-chloropyrid-4-yl)benzamide, 3-Cyclopropylmethoxy-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide, 1xmu, Roflumilast (Daxas), Roflumilast (JAN/USAN/INN)

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Roflumilast?

The CAS Registry Number of Roflumilast is 162401-32-3. It is also known as BY 217, Daxas, Libertek.

What is the molecular formula and molecular weight of Roflumilast?

Roflumilast has the molecular formula C17H14Cl2F2N2O3 and a molecular weight of 403.2 g/mol. Its IUPAC name is 3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide.

What is Roflumilast used for?

Roflumilast is supplied as a characterised reference material related to Roflumilast. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Roflumilast can I order?

We supply Roflumilast in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Roflumilast?

Yes. Every lot of Roflumilast is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Roflumilast be shipped internationally?

Yes. Roflumilast is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.