Tacrolimus Monohydrate

About Tacrolimus Monohydrate

Tacrolimus Monohydrate is a high-purity reference standard of Tacrolimus carrying the CAS registry number 109581-93-3. Formula C44H71NO13, molecular weight 822.0 g/mol. It is also known as Tacrolimus Hydrate or Tacrolimus hydrate (JP17).

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Danger” with 1 hazard statement. Review the Safety Data Sheet before use.

As a reference sample of Tacrolimus, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Tacrolimus

View every impurity, metabolite and intermediate we list for Tacrolimus.

Tacrolimus impurities

Specifications & identifiers

Chemical identifiers
Product name	Tacrolimus Monohydrate
Catalogue No.	VQ-028163
CAS Number	109581-93-3
IUPAC name	(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-1,14-dihydroxy-12-[(E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-prop-2-enyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone;hydrate
Molecular formula	C₄₄H₇₁NO₁₃
Molecular weight	822 g/mol
Exact mass	821.4925
Grade	Reference Standard
HSN code	38229090
InChIKey	NWJQLQGQZSIBAF-MLAUYUEBSA-N
SMILES	C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC.O
PubChem CID	5282315

Physical properties
Physical form	Solid
H-bond donors / acceptors	4 / 13
TPSA	179 Å²
Synonyms	Tacrolimus Hydrate, Tacrolimus hydrate (JP17), Tsukubaenolide hydrate, FK506 monohydrate, Tacrolimus hydrate (JP19), EX-A2657, Tacrolimus monohydrate - Bio-X trade mark

Safety & hazard information (GHS)

Toxic

Signal word: Danger

Hazard statements

H301Toxic if swallowed

Precautionary statements: P264, P270, P301 + P316, P321, P330, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Tacrolimus Monohydrate?

The CAS Registry Number of Tacrolimus Monohydrate is 109581-93-3. It is also known as Tacrolimus Hydrate, Tacrolimus hydrate (JP17), Tsukubaenolide hydrate.

What is the molecular formula and molecular weight of Tacrolimus Monohydrate?

Tacrolimus Monohydrate has the molecular formula C44H71NO13 and a molecular weight of 822 g/mol.

What is Tacrolimus Monohydrate used for?

Tacrolimus Monohydrate is supplied as a characterised reference material related to Tacrolimus. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Tacrolimus Monohydrate can I order?

We supply Tacrolimus Monohydrate in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Tacrolimus Monohydrate?

Yes. Every lot of Tacrolimus Monohydrate is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Tacrolimus Monohydrate be shipped internationally?

Yes. Tacrolimus Monohydrate is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.