Aprocitentan

Name: Aprocitentan
Brand: Vaqora Chemicals
SKU: VQ-023020

About Aprocitentan

Listed under CAS 1103522-45-7, Aprocitentan is an impurity of Macitentan available from Vaqora Chemicals. The compound has the formula C16H14Br2N6O4S, corresponding to a molecular weight of 546.2 g/mol. Systematically, it is named 5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine. Alternative names: N-Despropyl Macitentan and Macitentan metabolite m6.

The product is provided as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. Good laboratory practice and suitable PPE are recommended during handling.

Pharmaceutical QC and development laboratories use this impurity standard of Macitentan to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Macitentan

View every impurity, metabolite and intermediate we list for Macitentan.

Macitentan impurities

Specifications & identifiers

Chemical identifiers
Product name	Aprocitentan
Catalogue No.	VQ-023020
CAS Number	1103522-45-7
IUPAC name	5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine
Molecular formula	C₁₆H₁₄Br₂N₆O₄S
Molecular weight	546.2 g/mol
Exact mass	545.9144
Grade	Reference Standard
HSN code	38229090
InChIKey	DKULOVKANLVDEA-UHFFFAOYSA-N
SMILES	C1=CC(=CC=C1C2=C(N=CN=C2OCCOC3=NC=C(C=N3)Br)NS(=O)(=O)N)Br
PubChem CID	25099191

Physical properties
Physical form	Solid
LogP (XLogP3)	2.4
H-bond donors / acceptors	2 / 10
TPSA	151 Å²
Synonyms	N-Despropyl Macitentan, Macitentan metabolite m6, Sulfamide, N-(5-(4-bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-, 5-(4-bromophenyl)-4-(2-(5-bromopyrimidin-2-yl)oxyethoxy)-6-(sulfamoylamino)pyrimidine, N-Despropyl-macitentan, EX-A4419, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]Sulfamide, [5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]-ethoxy]-4-pyrimidinyl]sulfamide, 5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(sulfamoyl)pyrimidin-4-amine, Sulfamide, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy] ethoxy]-4-pyrimidinyl]

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Aprocitentan?

The CAS Registry Number of Aprocitentan is 1103522-45-7. It is also known as N-Despropyl Macitentan, Macitentan metabolite m6, Sulfamide, N-(5-(4-bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-.

What is the molecular formula and molecular weight of Aprocitentan?

Aprocitentan has the molecular formula C16H14Br2N6O4S and a molecular weight of 546.2 g/mol. Its IUPAC name is 5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine.

What is Aprocitentan used for?

Aprocitentan is supplied as a characterised reference material related to Macitentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Aprocitentan can I order?

We supply Aprocitentan in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Aprocitentan?

Yes. Every lot of Aprocitentan is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Aprocitentan be shipped internationally?

Yes. We export Aprocitentan worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.