Nebivolol

Name: Nebivolol
Brand: Vaqora Chemicals
SKU: VQ-023219

About Nebivolol

Listed under CAS 118457-14-0, Nebivolol is a high-purity reference standard of Nebivolol available from Vaqora Chemicals. Its molecular formula is C22H25F2NO4 and its molecular weight is 405.4 g/mol. Alternative names: Rel-Nebivolol and Nebivolol (R,S,S,S).

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 6 hazard statements. Review the Safety Data Sheet before use.

Laboratories use this Nebivolol standard for identity and assay testing, system suitability checks and method validation supporting ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Nebivolol

View every impurity, metabolite and intermediate we list for Nebivolol.

Nebivolol impurities

Specifications & identifiers

Chemical identifiers
Product name	Nebivolol
Catalogue No.	VQ-023219
CAS Number	118457-14-0
IUPAC name	1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol
Molecular formula	C₂₂H₂₅F₂NO₄
Molecular weight	405.4 g/mol
Exact mass	405.1752
Grade	Reference Standard
HSN code	38229090
InChIKey	KOHIRBRYDXPAMZ-UHFFFAOYSA-N
SMILES	C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O
PubChem CID	71301

Physical properties
Physical form	Solid
LogP (XLogP3)	3
H-bond donors / acceptors	3 / 7
TPSA	71 Å²
Synonyms	Rel-Nebivolol, Nebivolol (R,S,S,S), Nebivolol L Isomer, Narbivolol, dl-Nebivolol, nebibolol, Hydrochloride, Nebivolol, alpha,alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro)-2H-1-benzopyran-2-methanol, (Rac)-Nebivolol, 2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol), 1-(6-fluorochroman-2-yl)-2-[[2-(6-fluorochroman-2-yl)-2-hydroxy-ethyl]amino]ethanol, alpha,alpha'-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]

Safety & hazard information (GHS)

Harmful / irritant

Health hazard

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child

Precautionary statements: P203, P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P318, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Nebivolol?

The CAS Registry Number of Nebivolol is 118457-14-0. It is also known as Rel-Nebivolol, Nebivolol (R,S,S,S), Nebivolol L Isomer.

What is the molecular formula and molecular weight of Nebivolol?

Nebivolol has the molecular formula C22H25F2NO4 and a molecular weight of 405.4 g/mol. Its IUPAC name is 1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol.

What is Nebivolol used for?

Nebivolol is supplied as a characterised reference material related to Nebivolol. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Nebivolol can I order?

We supply Nebivolol in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Nebivolol?

Yes. Every lot of Nebivolol is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Nebivolol be shipped internationally?

Yes. Nebivolol is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.