Macitentan-d4

About Macitentan-d4

Macitentan-d4 is a stable isotope labelled analogue related to Macitentan carrying the CAS registry number 1258428-05-5. With the molecular formula C19H20Br2N6O4S, it has a molar mass of 592.3 g/mol.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Its mass shift relative to the unlabelled analyte makes it a dependable internal standard for LC-MS/MS assays, improving accuracy in bioanalysis, therapeutic drug monitoring and method validation. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

LC-MS/MS internal standard
Bioanalytical quantitation
Pharmacokinetic studies

Industries

Related to Macitentan

View every impurity, metabolite and intermediate we list for Macitentan.

Macitentan impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Macitentan-d4
Catalogue No.	VQ-038241
CAS Number	1258428-05-5
IUPAC name	5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxy-1,1,2,2-tetradeuterioethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine
Molecular formula	C₁₉H₂₀Br₂N₆O₄S
Molecular weight	592.3 g/mol
Exact mass	591.9864
Grade	Reference Standard
HSN code	38229090
InChIKey	JGCMEBMXRHSZKX-LZMSFWOYSA-N
SMILES	[2H]C([2H])(C([2H])([2H])OC1=NC=C(C=N1)Br)OC2=NC=NC(=C2C3=CC=C(C=C3)Br)NS(=O)(=O)NCCC
PubChem CID	49849030

Physical properties
Physical form	Solid
LogP (XLogP3)	3.7
H-bond donors / acceptors	2 / 10
TPSA	137 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Macitentan-d4?

The CAS Registry Number of Macitentan-d4 is 1258428-05-5.

What is the molecular formula and molecular weight of Macitentan-d4?

Macitentan-d4 has the molecular formula C19H20Br2N6O4S and a molecular weight of 592.3 g/mol. Its IUPAC name is 5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxy-1,1,2,2-tetradeuterioethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine.

What is Macitentan-d4 used for?

Macitentan-d4 is supplied as a characterised reference material related to Macitentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Macitentan-d4 can I order?

We supply Macitentan-d4 in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Macitentan-d4?

Yes. Every lot of Macitentan-d4 is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Macitentan-d4 be shipped internationally?

Yes. We export Macitentan-d4 worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.