5-(4-Bromophenyl)-4,6-dichloropyrimidine

Name: 5-(4-Bromophenyl)-4,6-dichloropyrimidine
Brand: Vaqora Chemicals
SKU: VQ-023370

About 5-(4-Bromophenyl)-4,6-dichloropyrimidine

5-(4-Bromophenyl)-4,6-dichloropyrimidine (CAS 146533-41-7) is an impurity of Macitentan offered by Vaqora Chemicals. Its molecular formula is C10H5BrCl2N2 and its molecular weight is 303.97 g/mol. Alternative names: Pyrimidine, 5-(4-bromophenyl)-4,6-dichloro- and 4,6-Dichloro-5-(4-bromophenyl)pyrimidine.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. Under GHS it is labelled “Warning”, so handle it with suitable PPE and consult the SDS.

Pharmaceutical QC and development laboratories use this impurity standard of Macitentan to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. It is used across pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, 5-(4-Bromophenyl)-4,6-dichloropyrimidine is dispatched with a Certificate of Analysis (COA) to destinations worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Macitentan

View every impurity, metabolite and intermediate we list for Macitentan.

Macitentan impurities

Specifications & identifiers

Chemical identifiers
Product name	5-(4-Bromophenyl)-4,6-dichloropyrimidine
Catalogue No.	VQ-023370
CAS Number	146533-41-7
IUPAC name	5-(4-bromophenyl)-4,6-dichloropyrimidine
Molecular formula	C₁₀H₅BrCl₂N₂
Molecular weight	303.97 g/mol
Exact mass	301.9013
Grade	Reference Standard
HSN code	38229090
InChIKey	WEEFLZORZXLIJE-UHFFFAOYSA-N
SMILES	C1=CC(=CC=C1C2=C(N=CN=C2Cl)Cl)Br
PubChem CID	19735262

Physical properties
Physical form	Solid
LogP (XLogP3)	4.4
H-bond donors / acceptors	0 / 2
TPSA	25.8 Å²

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation

Precautionary statements: P261, P264, P264 + P265, P272, P280, P302 + P352, P305 + P351 + P338, P321, P332 + P317, P333 + P317, P337 + P317, P362 + P364, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 5-(4-Bromophenyl)-4,6-dichloropyrimidine?

The CAS Registry Number of 5-(4-Bromophenyl)-4,6-dichloropyrimidine is 146533-41-7. It is also known as Pyrimidine, 5-(4-bromophenyl)-4,6-dichloro-, 4,6-Dichloro-5-(4-bromophenyl)pyrimidine, CS-M1491.

What is the molecular formula and molecular weight of 5-(4-Bromophenyl)-4,6-dichloropyrimidine?

5-(4-Bromophenyl)-4,6-dichloropyrimidine has the molecular formula C10H5BrCl2N2 and a molecular weight of 303.97 g/mol. Its IUPAC name is 5-(4-bromophenyl)-4,6-dichloropyrimidine.

What is 5-(4-Bromophenyl)-4,6-dichloropyrimidine used for?

5-(4-Bromophenyl)-4,6-dichloropyrimidine is supplied as a characterised reference material related to Macitentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 5-(4-Bromophenyl)-4,6-dichloropyrimidine can I order?

We supply 5-(4-Bromophenyl)-4,6-dichloropyrimidine in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 5-(4-Bromophenyl)-4,6-dichloropyrimidine?

Yes. Every lot of 5-(4-Bromophenyl)-4,6-dichloropyrimidine is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 5-(4-Bromophenyl)-4,6-dichloropyrimidine be shipped internationally?

Yes. 5-(4-Bromophenyl)-4,6-dichloropyrimidine is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.