4-Chloro-3-nitrobenzoic acid methyl ester

About 4-Chloro-3-nitrobenzoic acid methyl ester

4-Chloro-3-nitrobenzoic acid methyl ester is an impurity of Nintedanib carrying the CAS registry number 14719-83-6. Formula C8H6ClNO4, molecular weight 215.59 g/mol. The IUPAC name is methyl 4-chloro-3-nitrobenzoate. Alternative names: Methyl 4-chloro-3-nitrobenzate and Benzoic acid, 4-chloro-3-nitro-, methyl ester.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. It carries the GHS signal word “Warning” with 4 hazard statements. Review the Safety Data Sheet before use.

This Nintedanib impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Nintedanib

View every impurity, metabolite and intermediate we list for Nintedanib.

Nintedanib impurities

Specifications & identifiers

Chemical identifiers
Product name	4-Chloro-3-nitrobenzoic acid methyl ester
Catalogue No.	VQ-026914
CAS Number	14719-83-6
IUPAC name	methyl 4-chloro-3-nitrobenzoate
Molecular formula	C₈H₆ClNO₄
Molecular weight	215.59 g/mol
Exact mass	214.9985
Grade	Reference Standard
HSN code	38229090
InChIKey	XRTKWPWDSUNLHS-UHFFFAOYSA-N
SMILES	COC(=O)C1=CC(=C(C=C1)Cl)[N+](=O)[O-]
PubChem CID	735797

Physical properties
Physical form	Solid
LogP (XLogP3)	2.1
H-bond donors / acceptors	0 / 4
TPSA	72.1 Å²
Synonyms	Methyl 4-chloro-3-nitrobenzate, Benzoic acid, 4-chloro-3-nitro-, methyl ester, Methyl4-chloro-3-nitrobenzate, methyl-3-nitro-4-chlorobenzoate, Methyl 3-nitro-4-chlorobenzoate, methyl 4-chloro-3-nitro-benzoate

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 4-Chloro-3-nitrobenzoic acid methyl ester?

The CAS Registry Number of 4-Chloro-3-nitrobenzoic acid methyl ester is 14719-83-6. It is also known as Methyl 4-chloro-3-nitrobenzate, Benzoic acid, 4-chloro-3-nitro-, methyl ester, Methyl4-chloro-3-nitrobenzate.

What is the molecular formula and molecular weight of 4-Chloro-3-nitrobenzoic acid methyl ester?

4-Chloro-3-nitrobenzoic acid methyl ester has the molecular formula C8H6ClNO4 and a molecular weight of 215.59 g/mol. Its IUPAC name is methyl 4-chloro-3-nitrobenzoate.

What is 4-Chloro-3-nitrobenzoic acid methyl ester used for?

4-Chloro-3-nitrobenzoic acid methyl ester is supplied as a characterised reference material related to Nintedanib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 4-Chloro-3-nitrobenzoic acid methyl ester can I order?

We supply 4-Chloro-3-nitrobenzoic acid methyl ester in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 4-Chloro-3-nitrobenzoic acid methyl ester?

Yes. Every lot of 4-Chloro-3-nitrobenzoic acid methyl ester is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 4-Chloro-3-nitrobenzoic acid methyl ester be shipped internationally?

Yes. 4-Chloro-3-nitrobenzoic acid methyl ester is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.