Bosentan USP Related Compound B

Name: Bosentan USP Related Compound B
Brand: Vaqora Chemicals
SKU: VQ-006273

About Bosentan USP Related Compound B

Listed under CAS 174227-14-6, Bosentan USP Related Compound B is a pharmacopeial impurity of Bosentan available from Vaqora Chemicals. With the molecular formula C25H25N5O5S, it has a molar mass of 507.6 g/mol. The IUPAC name is 4-tert-butyl-N-[5-(2-methoxyphenoxy)-6-oxo-2-pyrimidin-2-yl-1H-pyrimidin-4-yl]benzenesulfonamide. Alternative names: O-Deshydroxyethyl Bosentan and Bosentan Impurity D.

It is supplied as a solid. Keep the vial tightly closed, protected from light and humidity, at the temperature stated on the Certificate of Analysis. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Bosentan to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Bosentan USP Related Compound B is dispatched with a Certificate of Analysis (COA) to destinations worldwide. Stock is available for quick dispatch.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Bosentan

View every impurity, metabolite and intermediate we list for Bosentan.

Bosentan impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Bosentan USP Related Compound B
Catalogue No.	VQ-006273
CAS Number	174227-14-6
IUPAC name	4-tert-butyl-N-[5-(2-methoxyphenoxy)-6-oxo-2-pyrimidin-2-yl-1H-pyrimidin-4-yl]benzenesulfonamide
Molecular formula	C₂₅H₂₅N₅O₅S
Molecular weight	507.6 g/mol
Exact mass	507.1576
Grade	Reference Standard
HSN code	38229090
InChIKey	REEANFGHAAWSIZ-UHFFFAOYSA-N
SMILES	CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=O)NC(=N2)C3=NC=CC=N3)OC4=CC=CC=C4OC
PubChem CID	135870740

Physical properties
Physical form	Solid
LogP (XLogP3)	3.7
H-bond donors / acceptors	2 / 9
TPSA	140 Å²
Synonyms	O-Deshydroxyethyl Bosentan, 4-tert-Butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide, 4-tert-butyl-n-(6-hydroxy-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide, Bosentan Impurity D, Bosentan USP RC B, CS-M2104, 4-(tert-butyl)-N-(6-hydroxy-5-(2-methoxyphenoxy)-[2,2-bipyrimidin]-4-yl)benzenesulfonamide

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements: P261, P264, P264 + P265, P271, P280, P302 + P352, P304 + P340, P305 + P351 + P338, P319, P321, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Bosentan USP Related Compound B?

The CAS Registry Number of Bosentan USP Related Compound B is 174227-14-6. It is also known as O-Deshydroxyethyl Bosentan, 4-tert-Butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide, 4-tert-butyl-n-(6-hydroxy-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide.

What is the molecular formula and molecular weight of Bosentan USP Related Compound B?

Bosentan USP Related Compound B has the molecular formula C25H25N5O5S and a molecular weight of 507.6 g/mol. Its IUPAC name is 4-tert-butyl-N-[5-(2-methoxyphenoxy)-6-oxo-2-pyrimidin-2-yl-1H-pyrimidin-4-yl]benzenesulfonamide.

What is Bosentan USP Related Compound B used for?

Bosentan USP Related Compound B is supplied as a characterised reference material related to Bosentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Bosentan USP Related Compound B can I order?

We supply Bosentan USP Related Compound B in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Bosentan USP Related Compound B?

Yes. Every lot of Bosentan USP Related Compound B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Bosentan USP Related Compound B be shipped internationally?

Yes. Bosentan USP Related Compound B is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.