Afatinib Hydroxy impurity

Name: Afatinib Hydroxy impurity
Brand: Vaqora Chemicals
SKU: VQ-020750

About Afatinib Hydroxy impurity

Afatinib Hydroxy impurity is a metabolite or degradation product of Afatinib carrying the CAS registry number 2223677-61-8. With the molecular formula C20H19ClFN5O2, it has a molar mass of 415.8 g/mol. The IUPAC name is (E)-N-[4-(3-chloro-4-fluoroanilino)-7-hydroxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide. Common synonyms include Afatinib Hydroxyquinazolin Impurity and Afatinib impurity V.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Good laboratory practice and suitable PPE are recommended during handling.

Analytical teams use this compound to identify metabolites and degradants of Afatinib, to validate stability-indicating methods (AMV) and to support QC and regulatory filings. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Afatinib Hydroxy impurity in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Metabolite identification
Stability-indicating methods
Impurity profiling

Industries

Related to Afatinib

View every impurity, metabolite and intermediate we list for Afatinib.

Afatinib impurities

Specifications & identifiers

Chemical identifiers
Product name	Afatinib Hydroxy impurity
Catalogue No.	VQ-020750
CAS Number	2223677-61-8
IUPAC name	(E)-N-[4-(3-chloro-4-fluoroanilino)-7-hydroxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
Molecular formula	C₂₀H₁₉ClFN₅O₂
Molecular weight	415.8 g/mol
Exact mass	415.1211
Grade	Reference Standard
HSN code	38229090
InChIKey	VOPXRQCNCZEDLI-ONEGZZNKSA-N
SMILES	CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O
PubChem CID	136478438

Physical properties
Physical form	Solid
LogP (XLogP3)	3.3
H-bond donors / acceptors	3 / 7
TPSA	90.4 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Afatinib Hydroxy impurity?

The CAS Registry Number of Afatinib Hydroxy impurity is 2223677-61-8. It is also known as Afatinib Hydroxyquinazolin Impurity, Afatinib impurity V.

What is the molecular formula and molecular weight of Afatinib Hydroxy impurity?

Afatinib Hydroxy impurity has the molecular formula C20H19ClFN5O2 and a molecular weight of 415.8 g/mol. Its IUPAC name is (E)-N-[4-(3-chloro-4-fluoroanilino)-7-hydroxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide.

What is Afatinib Hydroxy impurity used for?

Afatinib Hydroxy impurity is supplied as a characterised reference material related to Afatinib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Afatinib Hydroxy impurity can I order?

We supply Afatinib Hydroxy impurity in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Afatinib Hydroxy impurity?

Yes. Every lot of Afatinib Hydroxy impurity is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Afatinib Hydroxy impurity be shipped internationally?

Yes. We export Afatinib Hydroxy impurity worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.