5-Desbromo-5-Chloro Macitentan

Name: 5-Desbromo-5-Chloro Macitentan
Brand: Vaqora Chemicals
SKU: VQ-021269

About 5-Desbromo-5-Chloro Macitentan

5-Desbromo-5-Chloro Macitentan (CAS 2443747-63-3) is an impurity of Macitentan offered by Vaqora Chemicals. With the molecular formula C19H20BrClN6O4S, it has a molar mass of 543.8 g/mol. Systematically, it is named 5-(4-bromophenyl)-6-[2-(5-chloropyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine. Common synonyms include CS-M2653.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

Pharmaceutical QC and development laboratories use this impurity standard of Macitentan to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Buyers come mainly from pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Macitentan

View every impurity, metabolite and intermediate we list for Macitentan.

Macitentan impurities

Specifications & identifiers

Chemical identifiers
Product name	5-Desbromo-5-Chloro Macitentan
Catalogue No.	VQ-021269
CAS Number	2443747-63-3
IUPAC name	5-(4-bromophenyl)-6-[2-(5-chloropyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine
Molecular formula	C₁₉H₂₀BrClN₆O₄S
Molecular weight	543.8 g/mol
Exact mass	542.0139
Grade	Reference Standard
HSN code	38229090
InChIKey	ZAECTGVKYBAJMM-UHFFFAOYSA-N
SMILES	CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Cl)C3=CC=C(C=C3)Br
PubChem CID	78358426

Physical properties
Physical form	Solid
LogP (XLogP3)	3.7
H-bond donors / acceptors	2 / 10
TPSA	137 Å²

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of 5-Desbromo-5-Chloro Macitentan?

The CAS Registry Number of 5-Desbromo-5-Chloro Macitentan is 2443747-63-3. It is also known as CS-M2653.

What is the molecular formula and molecular weight of 5-Desbromo-5-Chloro Macitentan?

5-Desbromo-5-Chloro Macitentan has the molecular formula C19H20BrClN6O4S and a molecular weight of 543.8 g/mol. Its IUPAC name is 5-(4-bromophenyl)-6-[2-(5-chloropyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine.

What is 5-Desbromo-5-Chloro Macitentan used for?

5-Desbromo-5-Chloro Macitentan is supplied as a characterised reference material related to Macitentan. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of 5-Desbromo-5-Chloro Macitentan can I order?

We supply 5-Desbromo-5-Chloro Macitentan in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with 5-Desbromo-5-Chloro Macitentan?

Yes. Every lot of 5-Desbromo-5-Chloro Macitentan is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can 5-Desbromo-5-Chloro Macitentan be shipped internationally?

Yes. We export 5-Desbromo-5-Chloro Macitentan worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.