Clozapine EP Impurity B

About Clozapine EP Impurity B

Clozapine EP Impurity B is a pharmacopeial impurity of Clozapine carrying the CAS registry number 263366-81-0. The compound has the formula C30H24Cl2N6, corresponding to a molecular weight of 539.5 g/mol. The IUPAC name is 3-chloro-6-[4-(3-chloro-11H-benzo[b][1,4]benzodiazepin-6-yl)piperazin-1-yl]-11H-benzo[b][1,4]benzodiazepine. Common synonyms include Clozapine - Impurity B and Clozapine Impurity B.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Handle it with standard laboratory precautions and appropriate personal protective equipment.

This Clozapine impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. It is used across pharmaceutical manufacturing and academic and industrial research.

We offer Clozapine EP Impurity B in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Clozapine

View every impurity, metabolite and intermediate we list for Clozapine.

Clozapine impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Clozapine EP Impurity B
Catalogue No.	VQ-022254
CAS Number	263366-81-0
IUPAC name	3-chloro-6-[4-(3-chloro-11H-benzo[b][1,4]benzodiazepin-6-yl)piperazin-1-yl]-11H-benzo[b][1,4]benzodiazepine
Molecular formula	C₃₀H₂₄Cl₂N₆
Molecular weight	539.5 g/mol
Exact mass	538.144
Grade	Reference Standard
HSN code	38229090
InChIKey	IDGKXLZQFLSYEI-UHFFFAOYSA-N
SMILES	C1CN(CCN1C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42)C5=NC6=C(C=CC(=C6)Cl)NC7=CC=CC=C75
PubChem CID	135398959

Physical properties
Physical form	Solid
LogP (XLogP3)	6.1
H-bond donors / acceptors	2 / 4
TPSA	55.3 Å²
Synonyms	Clozapine - Impurity B, 11,11'-(Piperazine-1,4-diyl)-bis-8-chloro-5H-dibenze[b,e][1,4]-diazepine, 1,4-Bis(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)piperazine, N-Desmethyl 8-Chloro-5H-dibenzo[b,e][1,4]diazepine Clozapine, 11,11-(Piperazine-1,4-diyl)bis(8-chloro-5H-dibenzo(b,E)(1,4)diazepine), Clozapine Impurity B, 11,11'-(Piperazine-1,4-diyl)bis(8-chloro-5H-dibenzo[b,e][1,4]-diazepine), 11,11'-(Piperazine-1,4-diyl)-bis-8-chloro-5H-dibenze[b,e][1,4]diazepine, 11,11'-(Piperazine-1,4-diyl)bis(8-chloro-10H-dibenzo[b,e][1,4]diazepine)

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Clozapine EP Impurity B?

The CAS Registry Number of Clozapine EP Impurity B is 263366-81-0. It is also known as Clozapine - Impurity B, 11,11'-(Piperazine-1,4-diyl)-bis-8-chloro-5H-dibenze[b,e][1,4]-diazepine, 1,4-Bis(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)piperazine.

What is the molecular formula and molecular weight of Clozapine EP Impurity B?

Clozapine EP Impurity B has the molecular formula C30H24Cl2N6 and a molecular weight of 539.5 g/mol. Its IUPAC name is 3-chloro-6-[4-(3-chloro-11H-benzo[b][1,4]benzodiazepin-6-yl)piperazin-1-yl]-11H-benzo[b][1,4]benzodiazepine.

What is Clozapine EP Impurity B used for?

Clozapine EP Impurity B is supplied as a characterised reference material related to Clozapine. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Clozapine EP Impurity B can I order?

We supply Clozapine EP Impurity B in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Clozapine EP Impurity B?

Yes. Every lot of Clozapine EP Impurity B is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Clozapine EP Impurity B be shipped internationally?

Yes. We export Clozapine EP Impurity B worldwide by air and sea freight or express courier, on EXW, FOB, CIF, CFR or DAP Incoterms, with full export documentation.