Naloxone EP Impurity D

Name: Naloxone EP Impurity D
Brand: Vaqora Chemicals
SKU: VQ-034871

About Naloxone EP Impurity D

Vaqora Chemicals supplies Naloxone EP Impurity D, a pharmacopeial impurity of Naloxone registered under CAS number 26451-92-3. Its molecular formula is C19H19NO4 and its molecular weight is 325.4 g/mol. Common synonyms include Naloxone Hydrochloride EP Impurity D and Naloxone Hydrochloride - Impurity D.

The product is provided as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. The GHS classification uses the signal word “Warning”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Naloxone, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Naloxone EP Impurity D in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Naloxone

View every impurity, metabolite and intermediate we list for Naloxone.

Naloxone impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Naloxone EP Impurity D
Catalogue No.	VQ-034871
CAS Number	26451-92-3
IUPAC name	(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Molecular formula	C₁₉H₁₉NO₄
Molecular weight	325.4 g/mol
Exact mass	325.1314
Grade	Reference Standard
HSN code	38229090
InChIKey	VHFYKBURRFNDQL-GRGSLBFTSA-N
SMILES	C=CCN1CC[C@]23[C@@H]4C(=O)C=C[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O
PubChem CID	9897757

Physical properties
Physical form	Solid
LogP (XLogP3)	1.4
H-bond donors / acceptors	2 / 5
TPSA	70 Å²
Synonyms	Naloxone Hydrochloride EP Impurity D, Naloxone Hydrochloride - Impurity D, 7,8-Didehydronaloxone, (5alpha)-7,8-Didehydro-4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)morphinan-6-one, Morphinan-6-one, 7,8-didehydro-4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, (5alpha)-, Naloxone hydrochloride dihydrate impurity D, 7,8-Didehydro Naloxone

Safety & hazard information (GHS)

Harmful / irritant

Signal word: Warning

Hazard statements

H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H336May cause drowsiness or dizziness

Precautionary statements: P261, P264, P264 + P265, P270, P271, P280, P301 + P317, P302 + P352, P304 + P340, P305 + P351 + P338, P317, P319, P321, P330, P332 + P317, P337 + P317, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Naloxone EP Impurity D?

The CAS Registry Number of Naloxone EP Impurity D is 26451-92-3. It is also known as Naloxone Hydrochloride EP Impurity D, Naloxone Hydrochloride - Impurity D, 7,8-Didehydronaloxone.

What is the molecular formula and molecular weight of Naloxone EP Impurity D?

Naloxone EP Impurity D has the molecular formula C19H19NO4 and a molecular weight of 325.4 g/mol. Its IUPAC name is (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one.

What is Naloxone EP Impurity D used for?

Naloxone EP Impurity D is supplied as a characterised reference material related to Naloxone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Naloxone EP Impurity D can I order?

We supply Naloxone EP Impurity D in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Naloxone EP Impurity D?

Yes. Every lot of Naloxone EP Impurity D is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Naloxone EP Impurity D be shipped internationally?

Yes. Naloxone EP Impurity D is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.