Sorafenib

Name: Sorafenib
Brand: Vaqora Chemicals
SKU: VQ-007761

About Sorafenib

Sorafenib (CAS 284461-73-0) is a high-purity reference standard of Sorafenib offered by Vaqora Chemicals. Formula C21H16ClF3N4O3, molecular weight 464.8 g/mol. The IUPAC name is 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide. It is also known as sorafenib tosilate hydrate or Sorafenib free base.

It is supplied as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. Under GHS it is labelled “Danger”, so handle it with suitable PPE and consult the SDS.

As a reference sample of Sorafenib, it is used for identification, assay and impurity-profiling work during analytical method development, validation (AMV) and routine QC. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Standard pack sizes are 10 mg, 25 mg, 50 mg and 100 mg, and every batch ships with a Certificate of Analysis (COA) and we export worldwide.

Typical applications

Identification & assay
Method development & validation
QC reference material

Industries

Related to Sorafenib

View every impurity, metabolite and intermediate we list for Sorafenib.

Sorafenib impurities

Specifications & identifiers

Chemical identifiers
Product name	Sorafenib
Catalogue No.	VQ-007761
CAS Number	284461-73-0
Other CAS	475207-59-1
IUPAC name	4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
Molecular formula	C₂₁H₁₆ClF₃N₄O₃
Molecular weight	464.8 g/mol
Exact mass	464.0863
Grade	Reference Standard
HSN code	38229090
InChIKey	MLDQJTXFUGDVEO-UHFFFAOYSA-N
SMILES	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
PubChem CID	216239

Physical properties
Physical form	Solid
LogP (XLogP3)	4.1
H-bond donors / acceptors	3 / 7
TPSA	92.4 Å²
Synonyms	4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide, sorafenib tosilate hydrate, Sorafenib free base, C21H16ClF3N4O3, Sorafenib (Nexavar), 284461-73-0 (free base), 1uwh, 3gcs, 3heg, 4asd, Hit compound, 8, Sorafenib (Base)

Safety & hazard information (GHS)

Health hazard

Environmental hazard

Signal word: Danger

Hazard statements

H351Suspected of causing cancer
H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
H372Causes damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H402Harmful to aquatic life
H410Very toxic to aquatic life with long lasting effects

Precautionary statements: P203, P260, P263, P264, P270, P273, P280, P318, P319, P391, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Sorafenib?

The CAS Registry Number of Sorafenib is 284461-73-0. It is also known as 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide, sorafenib tosilate hydrate, Sorafenib free base.

What is the molecular formula and molecular weight of Sorafenib?

Sorafenib has the molecular formula C21H16ClF3N4O3 and a molecular weight of 464.8 g/mol. Its IUPAC name is 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide.

What is Sorafenib used for?

Sorafenib is supplied as a characterised reference material related to Sorafenib. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Sorafenib can I order?

We supply Sorafenib in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Sorafenib?

Yes. Every lot of Sorafenib is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Sorafenib be shipped internationally?

Yes. Sorafenib is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.