Naloxone EP Impurity A

Name: Naloxone EP Impurity A
Brand: Vaqora Chemicals
SKU: VQ-006518

About Naloxone EP Impurity A

Vaqora Chemicals supplies Naloxone EP Impurity A, a pharmacopeial impurity of Naloxone registered under CAS number 33522-95-1 with a typical assay of 53.90%. With the molecular formula C16H17NO4, it has a molar mass of 287.31 g/mol. Its systematic (IUPAC) name is (4R,4aS,7aR,12bS)-4a,9-dihydroxy-1,2,3,4,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one. It is also known as 4,5α-Epoxy-3,14-dihydroxymorphinan-6-one or (5α)-4,5-Epoxy-3,14-dihydroxymorphinan-6-one.

It is supplied as a solid. Store the standard in its sealed vial, protected from light and moisture, and follow the storage condition printed on the COA. It carries the GHS signal word “Danger” with 7 hazard statements. Review the Safety Data Sheet before use.

This Naloxone impurity supports analytical method development and validation (AMV), batch release testing and the impurity sections of ANDA and DMF filings. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

Available in 10 mg, 25 mg, 50 mg and 100 mg packs, Naloxone EP Impurity A is dispatched with a Certificate of Analysis (COA) to destinations worldwide. Stock is available for quick dispatch.

Typical applications

Pharmacopeial method verification
Impurity profiling
QC release testing
ANDA / DMF filings

Industries

Related to Naloxone

View every impurity, metabolite and intermediate we list for Naloxone.

Naloxone impurities

Grade guides

Specifications & identifiers

Chemical identifiers
Product name	Naloxone EP Impurity A
Catalogue No.	VQ-006518
CAS Number	33522-95-1
Other CAS	52446-24-9, 2162130-71-2
IUPAC name	(4R,4aS,7aR,12bS)-4a,9-dihydroxy-1,2,3,4,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
Molecular formula	C₁₆H₁₇NO₄
Molecular weight	287.31 g/mol
Exact mass	287.1158
Grade	Reference Standard
Purity / assay	53.90%
HSN code	38229090
InChIKey	HLMSIZPQBSYUNL-IPOQPSJVSA-N
SMILES	C1C[C@]2([C@H]3CC4=C5[C@@]2(CCN3)[C@H](C1=O)OC5=C(C=C4)O)O
PubChem CID	5497189

Physical properties
Physical form	Solid
LogP (XLogP3)	0.4
H-bond donors / acceptors	3 / 5
TPSA	78.8 Å²
Synonyms	4,5α-Epoxy-3,14-dihydroxymorphinan-6-one, (5α)-4,5-Epoxy-3,14-dihydroxymorphinan-6-one, (-)-Noroxymorphone, Noroxymorphone, 14-Hydroxydihydronormorphinone, 7,8-Dihydro-14-hydroxynormorphinone, Naltrexone Impurity B, Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-, (5alpha)-, Nor Oxymorphone, (5alpha)-4,5-Epoxy-3,14-dihydroxymorphinan-6-one, Nor Oxymorphone (1.0mg/ml in DMSO), desethenyl_naloxone

Safety & hazard information (GHS)

Toxic

Harmful / irritant

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H302+H332Harmful if swallowed or if inhaled
H302Harmful if swallowed
H312Harmful in contact with skin
H317May cause an allergic skin reaction
H332Harmful if inhaled
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements: P233, P260, P261, P264, P270, P271, P272, P280, P284, P301 + P316, P301 + P317, P302 + P352, P304 + P340, P317, P321, P330, P333 + P317, P342 + P316, P362 + P364, P403, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Naloxone EP Impurity A?

The CAS Registry Number of Naloxone EP Impurity A is 33522-95-1. It is also known as 4,5α-Epoxy-3,14-dihydroxymorphinan-6-one, (5α)-4,5-Epoxy-3,14-dihydroxymorphinan-6-one, (-)-Noroxymorphone.

What is the molecular formula and molecular weight of Naloxone EP Impurity A?

Naloxone EP Impurity A has the molecular formula C16H17NO4 and a molecular weight of 287.31 g/mol. Its IUPAC name is (4R,4aS,7aR,12bS)-4a,9-dihydroxy-1,2,3,4,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one.

What is Naloxone EP Impurity A used for?

Naloxone EP Impurity A is supplied as a characterised reference material related to Naloxone. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Naloxone EP Impurity A can I order?

We supply Naloxone EP Impurity A in Reference Standard (53.90%) grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Naloxone EP Impurity A?

Yes. Every lot of Naloxone EP Impurity A is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Naloxone EP Impurity A be shipped internationally?

Yes. Naloxone EP Impurity A is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.