Methotrexate diethyl ester

Name: Methotrexate diethyl ester
Brand: Vaqora Chemicals
SKU: VQ-026638

About Methotrexate diethyl ester

Listed under CAS 43170-88-3, Methotrexate diethyl ester is an impurity of Methotrexate available from Vaqora Chemicals. Formula C24H30N8O5, molecular weight 510.5 g/mol. Its systematic (IUPAC) name is diethyl (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate. It is also known as Diethyl methotrexate.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

Pharmaceutical QC and development laboratories use this impurity standard of Methotrexate to develop and validate HPLC methods, to set specification limits and to document impurity profiles in ANDA and DMF submissions. Typical end-use sectors are pharmaceutical manufacturing and academic and industrial research.

We offer Methotrexate diethyl ester in 10 mg, 25 mg, 50 mg and 100 mg packs with a batch-specific COA, and ship to customers worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Methotrexate

View every impurity, metabolite and intermediate we list for Methotrexate.

Methotrexate impurities

Specifications & identifiers

Chemical identifiers
Product name	Methotrexate diethyl ester
Catalogue No.	VQ-026638
CAS Number	43170-88-3
IUPAC name	diethyl (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate
Molecular formula	C₂₄H₃₀N₈O₅
Molecular weight	510.5 g/mol
Exact mass	510.2339
Grade	Reference Standard
HSN code	38229090
InChIKey	MZRRIAJJDAPQRO-KRWDZBQOSA-N
SMILES	CCOC(=O)CC[C@@H](C(=O)OCC)NC(=O)C1=CC=C(C=C1)N(C)CC2=CN=C3C(=N2)C(=NC(=N3)N)N
PubChem CID	94528

Physical properties
Physical form	Solid
LogP (XLogP3)	1
H-bond donors / acceptors	3 / 12
TPSA	189 Å²
Synonyms	Diethyl methotrexate, Diethyl N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamate, (S)-Diethyl 2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate, diethyl n-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-l-glutamate, diethyl (4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamate

Safety & hazard information (GHS)

Toxic

Health hazard

Signal word: Danger

Hazard statements

H301Toxic if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
H340May cause genetic defects
H351Suspected of causing cancer
H360May damage fertility or the unborn child

Precautionary statements: P203, P261, P262, P264, P264 + P265, P270, P271, P280, P301 + P316, P302 + P352, P304 + P340, P305 + P351 + P338, P316, P318, P319, P321, P330, P332 + P317, P337 + P317, P361 + P364, P362 + P364, P403 + P233, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Methotrexate diethyl ester?

The CAS Registry Number of Methotrexate diethyl ester is 43170-88-3. It is also known as Diethyl methotrexate, Diethyl N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamate, (S)-Diethyl 2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate.

What is the molecular formula and molecular weight of Methotrexate diethyl ester?

Methotrexate diethyl ester has the molecular formula C24H30N8O5 and a molecular weight of 510.5 g/mol. Its IUPAC name is diethyl (2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate.

What is Methotrexate diethyl ester used for?

Methotrexate diethyl ester is supplied as a characterised reference material related to Methotrexate. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Methotrexate diethyl ester can I order?

We supply Methotrexate diethyl ester in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Methotrexate diethyl ester?

Yes. Every lot of Methotrexate diethyl ester is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Methotrexate diethyl ester be shipped internationally?

Yes. Methotrexate diethyl ester is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.