Pyr-His-Trp-Ser-Tyr-OH

Name: Pyr-His-Trp-Ser-Tyr-OH
Brand: Vaqora Chemicals
SKU: VQ-037971

About Pyr-His-Trp-Ser-Tyr-OH

Vaqora Chemicals supplies Pyr-His-Trp-Ser-Tyr-OH, an impurity of Leuprolide registered under CAS number 52434-75-0. The compound has the formula C34H38N8O9, corresponding to a molecular weight of 702.7 g/mol. Common synonyms include LHRH (1-5) (free acid) and LHRH (1-5) (free acid) trifluoroacetate salt.

The product is provided as a solid. Reference materials should be stored sealed and away from light and moisture, as specified on the accompanying COA. The GHS classification uses the signal word “Danger”, so appropriate gloves, eye protection and ventilation are recommended.

As a characterised impurity of Leuprolide, it is used for analytical method development, method validation (AMV) and routine quality-control testing, and it supports ANDA and DMF regulatory filings. Our customers for this product work in pharmaceutical manufacturing and academic and industrial research.

Vaqora Chemicals supplies Pyr-His-Trp-Ser-Tyr-OH in 10 mg, 25 mg, 50 mg and 100 mg packs, each shipped with a Certificate of Analysis (COA), and exports worldwide.

Typical applications

Analytical method development
Method validation (AMV)
QC release testing
ANDA / DMF filings

Industries

Related to Leuprolide

View every impurity, metabolite and intermediate we list for Leuprolide.

Leuprolide impurities

Specifications & identifiers

Chemical identifiers
Product name	Pyr-His-Trp-Ser-Tyr-OH
Catalogue No.	VQ-037971
CAS Number	52434-75-0
IUPAC name	(2S)-2-[[(2S)-3-hydroxy-2-[[(2S)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
Molecular formula	C₃₄H₃₈N₈O₉
Molecular weight	702.7 g/mol
Exact mass	702.2762
Grade	Reference Standard
HSN code	38229090
InChIKey	VVBDLEHCIKUJSA-XLIKFSOKSA-N
SMILES	C1CC(=O)N[C@@H]1C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC5=CC=C(C=C5)O)C(=O)O
PubChem CID	13190525

Physical properties
Physical form	Solid
LogP (XLogP3)	-0.1
H-bond donors / acceptors	10 / 10
TPSA	268 Å²
Synonyms	LHRH (1-5) (free acid), LHRH (1-5) (free acid) trifluoroacetate salt, pGlu-His-Trp-Ser-Tyr, L-Tyrosine, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-, Pyr-His-Trp-Ser-Tyr-OH trifluoroacetate salt

Safety & hazard information (GHS)

Health hazard

Signal word: Danger

Hazard statements

H360May damage fertility or the unborn child

Precautionary statements: P203, P280, P318, P405, P501

Classification is indicative (aggregated GHS notifications) and may vary by grade and concentration. Always refer to the SDS supplied with your lot.

Documents

Safety Data Sheet (SDS)16-section GHS · on request Certificate of AnalysisTypical / batch COA · on request Specification sheetTDS / MOA · on request

Frequently asked questions

What is the CAS number of Pyr-His-Trp-Ser-Tyr-OH?

The CAS Registry Number of Pyr-His-Trp-Ser-Tyr-OH is 52434-75-0. It is also known as LHRH (1-5) (free acid), LHRH (1-5) (free acid) trifluoroacetate salt, pGlu-His-Trp-Ser-Tyr.

What is the molecular formula and molecular weight of Pyr-His-Trp-Ser-Tyr-OH?

Pyr-His-Trp-Ser-Tyr-OH has the molecular formula C34H38N8O9 and a molecular weight of 702.7 g/mol.

What is Pyr-His-Trp-Ser-Tyr-OH used for?

Pyr-His-Trp-Ser-Tyr-OH is supplied as a characterised reference material related to Leuprolide. It is used for analytical method development and validation (AMV), impurity profiling, stability studies and quality control, and in ANDA/DMF regulatory filings.

Which grade and pack sizes of Pyr-His-Trp-Ser-Tyr-OH can I order?

We supply Pyr-His-Trp-Ser-Tyr-OH in Reference Standard grade, in 10 mg, 25 mg, 50 mg, 100 mg packs. Larger bulk quantities and custom packing are quoted on request.

Do you provide a COA and SDS with Pyr-His-Trp-Ser-Tyr-OH?

Yes. Every lot of Pyr-His-Trp-Ser-Tyr-OH is shipped with a batch-specific Certificate of Analysis, and a 16-section GHS Safety Data Sheet is provided with the quotation and the shipment.

Can Pyr-His-Trp-Ser-Tyr-OH be shipped internationally?

Yes. Pyr-His-Trp-Ser-Tyr-OH is classified as hazardous, so it is packed in UN-approved packaging and shipped as dangerous goods under IATA/IMDG rules. We export worldwide on EXW, FOB, CIF and DAP terms.